Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism-Association with prostate cancer.

Autor: Álvarez-González B; University of Granada, Legal Medicine and Toxicology Department, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Granada, Spain., Hernández AF; University of Granada, Legal Medicine and Toxicology Department, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain; Biosanitary Research Institute, ibs.GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain. Electronic address: ajerez@ugr.es., Zafra-Gómez A; Biosanitary Research Institute, ibs.GRANADA, Granada, Spain; University of Granada, Department of Analytical Chemistry, Campus of Fuentenueva, Granada 18071, Spain., Chica-Redecillas L; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Granada, Spain; University of Granada, Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain., Cuenca-López S; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Granada, Spain; University of Granada, Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain., Vázquez-Alonso F; Urology Department, University Hospital Virgen de las Nieves, Av. de las Fuerzas Armadas 2, Granada, Spain., Martínez-González LJ; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Granada, Spain; University of Granada, Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain., Álvarez-Cubero MJ; GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Granada, Spain; Biosanitary Research Institute, ibs.GRANADA, Granada, Spain; University of Granada, Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, Health Sciences Technology Park (PTS), Granada, Spain.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Jun; Vol. 108, pp. 104455. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1016/j.etap.2024.104455
Abstrakt: This study assessed whether genetic variants coding for certain enzymes involved in xenobiotic detoxification, antioxidant defences and DNA repair, along with exposure to environmental chemicals, were associated with an increased prostate cancer (PCa) risk. The study population consisted of 300 men (150 PCa cases and 150 controls) which underwent prostate biopsy as their serum prostate specific antigen (PSA) levels were greater than 4 ng/ml. Genetic variants in GSTM1, GSTP1, SOD2, CAT, GPX1, XRCC1 were determined and data for chemical exposures was obtained through a structured questionnaire and by biomonitoring in a subsample of cases and controls. High serum PSA levels were associated with a greater risk of PCa, while physical exercise appears to exert a protective effect against its development. In addition, elevated urinary levels of certain organic pollutants, such as benzo(a)pyrene (BaP), bisphenol A (BPA), and ethyl-paraben (EPB), were associated with an increased risk of PCa.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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