Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children.

Autor: Khambati N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: nisreen.khambati@stcatz.ox.ac.uk., Song R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA USA; Department of Pediatrics, Harvard Medical School, Boston, MA USS., Smith JP; Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia, United States; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, United States., Bijker EM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Department of Pediatrics, Maastricht University Medical Center, MosaKids Children's Hospital, Maastricht, the Netherlands., McCarthy K; Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia, United States., Click ES; Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia, United States., Mchembere W; Kenya Medical Research Institute - Center for Global Health Research, Kisumu, Kenya., Okumu A; Kenya Medical Research Institute - Center for Global Health Research, Kisumu, Kenya., Musau S; Kenya Medical Research Institute - Center for Global Health Research, Kisumu, Kenya., Okeyo E; Kenya Medical Research Institute - Center for Global Health Research, Kisumu, Kenya., Perez-Velez CM; University of Arizona College of Medicine, Tucson, AZ USA., Cain K; Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia, United States.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Jul; Vol. 109 (3), pp. 116302. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1016/j.diagmicrobio.2024.116302
Abstrakt: For microbiological confirmation of pediatric pulmonary tuberculosis (PTB), gastric aspirates (GA) are often operationally unfeasible without hospitalization, and the encapsulated orogastric string test is not easily swallowed in young children. The Combined-NasoGastric-Tube-and-String-Test (CNGTST) enables dual collection of GA and string specimens. In a prospective cohort study in Kenya, we examined its feasibility in children under five with presumptive PTB and compared the bacteriological yield of string to GA. Paired GA and string samples were successfully collected in 95.6 % (281/294) of children. Mycobacterium tuberculosis was isolated from 7.0 % (38/541) of GA and 4.3 % (23/541) of string samples, diagnosing 8.2 % (23/281) of children using GA and 5.3 % (15/281) using string. The CNGTST was feasible in nearly all children. Yield from string was two-thirds that of GA despite a half-hour median dwelling time. In settings where the feasibility of hospitalisation for GA is uncertain, the string component can be used to confirm PTB.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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