Reference Value Fibrin Monomer in Healthy Children: A Cross-Sectional Study.

Autor:	Tuan TA; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., Xoay TD; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam.; Hanoi Medical University, Hanoi, Vietnam., My TTK; Hanoi Medical University, Hanoi, Vietnam., Duyen NT; Department of Hematology, Vietnam National Children's Hospital, Ha Noi, Vietnam., Trang NT; Department of Hematology, Vietnam National Children's Hospital, Ha Noi, Vietnam., Kien NT; Hanoi Medical University, Hanoi, Vietnam., Son CT; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam., Thang NV; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam., Quan TQ; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam., Hung DV; Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam.
Jazyk:	angličtina
Zdroj:	Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2024 Jan-Dec; Vol. 30, pp. 10760296241247560.
DOI:	10.1177/10760296241247560
Abstrakt:	The objective of this study is to determine the fibrin monomer reference intervals in healthy children. This cross-sectional study was conducted in the Hematology Department at Vietnam National Children's Hospital (April 2023 to March 2024). Children without prior history of clotting disorders or anticoagulants use hospitalized in preparation for orthopedic surgery or inguinal hernia surgery were enrolled in the study. The fibrin monomer test method was the quantitative fibrin monomer test on the STA-R system (Diagnostica Stago™, France). Eighty-six children (58 males and 28 females) were enrolled in the study. The median (interquartile range, 2.5th-97.5th) fibrin monomer value of the study subjects was 2.56 (0.11-5.93) µg/mL, with no statistically significant difference in fibrin monomer values among the age groups of 1 month to 3 years, 3 years to 13 years, and 13 years to 18 years. This is the first study conducted in Vietnam to determine reference values of fibrin monomer in children. This information can help in the diagnosis and treatment of early hypercoagulation stage and disseminated intravascular coagulation in children. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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