Brightness illusions drive a neuronal response in the primary visual cortex under top-down modulation.

Autor: Saeedi A; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany.; Research Group Neurobiology of Magnetoreception, Max Planck Institute for Neurobiology of Behavior - caesar, 53175, Bonn, Germany., Wang K; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany.; Department of Physiology of Cognitive Processes, International Center for Primate Brain Research, Songjiang District, Shanghai, 201602, China., Nikpourian G; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany., Bartels A; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany.; Department of Psychology, Vision and Cognition Lab, Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.; Bernstein Center for Computational Neuroscience, Tübingen, Germany., Logothetis NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany.; Department of Physiology of Cognitive Processes, International Center for Primate Brain Research, Songjiang District, Shanghai, 201602, China.; Centre for Imaging Sciences, University of Manchester, Manchester, M139PT, UK., Totah NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany. nelson.totah@helsinki.fi.; Helsinki Institute of Life Science (HILIFE), University of Helsinki, 00014, Helsinki, Finland. nelson.totah@helsinki.fi.; Faculty of Pharmacy, University of Helsinki, 00014, Helsinki, Finland. nelson.totah@helsinki.fi.; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland. nelson.totah@helsinki.fi., Watanabe M; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany. watanabe@sys.t.u-tokyo.ac.jp.; Department of Systems Innovation, School of Engineering, The University of Tokyo, Tokyo, Japan. watanabe@sys.t.u-tokyo.ac.jp.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 23; Vol. 15 (1), pp. 3141. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1038/s41467-024-46885-6
Abstrakt: Brightness illusions are a powerful tool in studying vision, yet their neural correlates are poorly understood. Based on a human paradigm, we presented illusory drifting gratings to mice. Primary visual cortex (V1) neurons responded to illusory gratings, matching their direction selectivity for real gratings, and they tracked the spatial phase offset between illusory and real gratings. Illusion responses were delayed compared to real gratings, in line with the theory that processing illusions requires feedback from higher visual areas (HVAs). We provide support for this theory by showing a reduced V1 response to illusions, but not real gratings, following HVAs optogenetic inhibition. Finally, we used the pupil response (PR) as an indirect perceptual report and showed that the mouse PR matches the human PR to perceived luminance changes. Our findings resolve debates over whether V1 neurons are involved in processing illusions and highlight the involvement of feedback from HVAs.
(© 2024. The Author(s).)
Databáze: MEDLINE
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