Integrative phytochemical, ligand structure based drug design nephroprotective potential of Annona muricata flower-petals.

Autor: Ololade ZS; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria., Onifade OF; Department of Chemical Sciences, Biochemistry Unit, Bells University of Technology, Ota, Nigeria., Eze JC; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria., Oyebanji OT; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria., Olaniran AC; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria., Anuoluwa IA; Department of Microbiology, University of Medical Sciences, Ondo, Nigeria., Idowu OO; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria., Tommy BE; Department of Chemistry, Medicinal and Organic Chemistry Unit, University of Medical Sciences, Ondo, Nigeria.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Apr 23, pp. 1-6. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1080/14786419.2024.2342554
Abstrakt: This study was aimed at investigating the ability of extract of Annona muricata (AM) flower-petals in ameliorating the toxic effects of acetaminophen on the kidneys of albino rats. The biochemical results showed a marked increase in AM 200 mg (32.84 ± 0.14) and AM 400 mg (32.64 ± 0.78). Increase levels of total protein in AM 200 mg (77.00 ± 5.65) displays nephroprotective potential of the flower extract. Reduction of renal activities of serum urea in AM 400 mg group (6.41 ± 0.22) indicates its protective potency against acetaminophen induced kidney damage. Increased activities of SOD levels at 200 mg (4.97 ± 0.05) and CAT levels at 200 mg (23.39 ± 1.13). This study showed that A. muricata has good prospects of being a nephroprotective drug candidate.
Databáze: MEDLINE
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