Variable Clinical Courses of Varicella Zoster Virus Infection-related or Vaccination-related Bone Marrow Failure.

Autor:	Toskov V; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg., Cseh A; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.; Department of Stem Cell Transplantation, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria., Claviez A; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel., Drexler B; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.; Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland., Rotari N; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg., Schwarz-Furlan S; Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren.; Institute of Pathology, University Hospital Erlangen, Erlangen., Braun M; Department of Padiatrische Hamatologie und Onkologie, Zentrum fur Kinderheiikunde der Justus-Liebig-Universitat Giessen, Giessen., Bader P; Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main., Lang P; Department of Hematology/Oncology and General Pediatrics, Children's University Hospital, University of Tübingen, Tübingen., Beier R; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover., Erdlenbruch B; Department of Pediatrics, Johannes Wesling Klinikum Minden, Ruhr-University Bochum, Minden., Führer M; Center for Pediatric Palliative Care, Dr von Hauner Children's Hospital, University of Munich, Munich, Germany., Erlacher M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg., Niemeyer CM; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg., Strahm B; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg., Yoshimi A; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.
Jazyk:	angličtina
Zdroj:	Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2024 Jul 01; Vol. 46 (5), pp. e354-e359. Date of Electronic Publication: 2024 Apr 23.
DOI:	10.1097/MPH.0000000000002866
Abstrakt:	We report 5 children with bone marrow failure (BMF) after primary varicella zoster virus (VZV) infection or VZV vaccination, highlighting the highly variable course. Two patients were treated with intravenous immunoglobulins; one had a slow hematologic recovery, and the other was rescued by allogeneic hematopoietic stem cell transplantation (HSCT). Of the 2 patients treated with immunosuppressive therapy with antithymocyte globulin and cyclosporine, one had a complete response, and the other was transplanted for nonresponse. One patient underwent a primary allograft. All patients are alive. This study demonstrated that VZV-associated BMF is a life-threatening disorder that often requires HSCT. Competing Interests: The authors declare conflict of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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