Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry.

Autor: Niedoszytko M; Department of Allergology, Medical University of Gdansk, Gdansk, Poland., Gorska A; Department of Allergology, Medical University of Gdansk, Gdansk, Poland., Brockow K; Department of Dermatology and Allergy Biederstein, Technical University of Munich, School of Medicine, Munich, Germany., Bonadonna P; Allergy Unit, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Lange M; Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland., Kluin-Nelemans H; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Oude-Elberink H; Department of Allergology, University Medical Center, Groningen, The Netherlands., Sabato V; Department of Immunology, Allergology Rheumatology University of Antwerp and Antwerp University Hospital, Edegem, Belgium., Shoumariyeh K; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany and German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., von Bubnoff D; Dagmar von Bubnoff, Department of Dermatology, Allergy and Venerology, University of Schleswig Holstein, Lübeck, Germany., Müller S; Department of Dermatology, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Illerhaus A; Dermatologie, Uniklinik Köln, Köln, Germany., Doubek M; Brno University Hospital, Brno, Czech Republic., Angelova-Fischer I; Department of Dermatology, Kepler University Hospital, Linz, Austria., Hermine O; Unit of Dermatology and CEREMAST, Pitié-Salpêtrière Hospital, Sorbonne Université, Paris, France., Arock M; Department of Hematological Biology and CEREMAST, Pitié-Salpêtrière Hospital, Paris Sorbonne University, Paris, France., Elena C; Department of Hematology, Fondazione IRCCS Fondazione Policlinico San Matteo, Pavia, Italy., Malcovati L; Department of Hematology, Fondazione IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Yavuz AS; Istanbul University, Istanbul Faculty of Medicine, Istanbul, Türkiye., Schug TD; Medical University of Graz, Univ.Klinik für Dermatologie, Graz, Austria., Fortina AB; Pediatric Dermatology, Internal Medicine, Azienda Ospedaliera, Università di Padova, Padova, Italy., Judit V; Semmelweis University Budapest, Budapest, Hungary., Gotlib J; Stanford University, School of Medicine, Hematology Clinic, Stanford, USA., Panse J; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Center for Integrated Oncology Aachen, Bonn Cologne, Duesseldorf (CIO ABCD), Aachen, Germany., Vucinic V; Universitätsklinikum Leipzig AöR, Leipzig, Germany., Reiter A; Universitätsmedizin Mannheim, III.Medizinische Klinik, Mannhein, Germany., Schwaab J; Universitätsmedizin Mannheim, III.Medizinische Klinik, Mannhein, Germany., Triggiani M; University of Salerno, Salerno, Italy., Mattsson M; Uppsala University Hospital, Uppsala, Sweden., Breynaert C; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology ResearchGroup and MASTeL, University Hospitals Leuven, Leuven, Belgium., Romantowski J; Department of Allergology, Medical University of Gdansk, Gdansk, Poland., Zanotti R; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy., Olivieri E; Allergy Unit, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Zink A; Department of Dermatology and Allergy Biederstein, Technical University of Munich, School of Medicine, Munich, Germany., van de Ven A; Department of Allergology, University Medical Center, Groningen, The Netherlands., Stefan A; Clinic for Hematology and Oncology, Kepler University Hospital, Linz, Austria., Barete S; Unit of Dermatology and CEREMAST, Pitié-Salpêtrière Hospital, Sorbonne Université, Paris, France., Caroppo F; Pediatric Dermatology, Internal Medicine, Azienda Ospedaliera, Università di Padova, Padova, Italy., Perkins C; Stanford University, School of Medicine, Hematology Clinic, Stanford, USA., Kennedy V; Stanford University, School of Medicine, Hematology Clinic, Stanford, USA., Christen D; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Center for Integrated Oncology Aachen, Bonn Cologne, Duesseldorf (CIO ABCD), Aachen, Germany., Jawhar M; Universitätsmedizin Mannheim, III.Medizinische Klinik, Mannhein, Germany.; Department of Hematology and Oncology, Helios Pforzheim, Pforzheim, Germany., Luebke J; Universitätsmedizin Mannheim, III.Medizinische Klinik, Mannhein, Germany., Parente R; University of Salerno, Salerno, Italy., Levedahl K; Uppsala University Hospital, Uppsala, Sweden.; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Hadzijusufovic E; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland., Nedoszytko B; Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.; Invicta Fertility and Reproductive Center, Molecular Laboratory, Sopot, Poland., Sperr WR; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2024 Sep; Vol. 79 (9), pp. 2470-2481. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1111/all.16132
Abstrakt: Background: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry.
Methods: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up. The study group consisted of 2485 adults with mastocytosis, 1379 women (55.5%) and 1106 men (44.5%). Median age was 48.2 years (range 18-91 years).
Results: Nine hundred and forty eight patients (38.1%) reported one or more HR`. Most common triggers were Hymenoptera venoms in cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM), whereas in advanced SM (advSM), most common elicitors were drugs, including nonsteroidal anti-inflammatory agents and penicillin. In multivariate analyses, tryptase level < 90 ng/mL, <15% infiltration by mast cells in bone marrow biopsy-sections, and diagnosis of ISM were identified as independent risk factors for HR. For drug-induced HR, prominent risk factors were advSM and high tryptase levels. New reactions were observed in 4.8% of all patients during 4 years follow-up.
Conclusions: HR are mainly triggered by Hymenoptera venoms in patients with CM and ISM and by drugs in patients with advSM. Tryptase levels <90 ng/mL, mast cell bone marrow infiltration <15%, and WHO category ISM are predictors of HR. New HR occur in 4.8% of all patients within 4 years.
(© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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