Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults.

Autor: Pivac LN; Centre for Healthy Ageing, Health Futures Institute Murdoch University Murdoch Western Australia Australia.; Alzheimer's Research Australia, Sarich Neuroscience Research Institute Nedlands Western Australia Australia., Brown BM; Centre for Healthy Ageing, Health Futures Institute Murdoch University Murdoch Western Australia Australia., Sewell KR; Centre for Healthy Ageing, Health Futures Institute Murdoch University Murdoch Western Australia Australia., Doecke JD; Australian E-Health Research Centre, CSIRO Herston Queensland Australia., Villemagne VL; Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA., Doré V; Australian E-Health Research Centre, CSIRO Herston Queensland Australia.; Department of Molecular Imaging Austin Health Heidelberg Victoria Australia., Weinborn M; School of Psychological Science University of Western Australia Perth Western Australia Australia., Sohrabi HR; Centre for Healthy Ageing, Health Futures Institute Murdoch University Murdoch Western Australia Australia., Gardener SL; School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia., Bucks RS; School of Psychological Science University of Western Australia Perth Western Australia Australia.; School of Population and Global Health University of Western Australia Perth Western Australia Australia., Laws SM; School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.; Centre for Precision Health Edith Cowan University Joondalup Western Australia Australia.; Collaborative Genomics and Translation Group Edith Cowan University Joondalup Western Australia Australia.; Curtin Medical School Curtin University Bentley Western Australia Australia., Taddei K; School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia., Maruff P; Cogstate Ltd., Melbourne Melbourne Victoria Australia.; The Florey Institute of Neuroscience and Mental Health University of Melbourne Melbourne Victoria Australia., Masters CL; The Florey Institute of Neuroscience and Mental Health University of Melbourne Melbourne Victoria Australia., Rowe C; Department of Molecular Imaging Austin Health Heidelberg Victoria Australia.; The Florey Institute of Neuroscience and Mental Health University of Melbourne Melbourne Victoria Australia., Martins RN; School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.; Department of Biomedical Sciences Macquarie University Macquarie University Sydney New South Wales Australia., Rainey-Smith SR; Centre for Healthy Ageing, Health Futures Institute Murdoch University Murdoch Western Australia Australia.; Alzheimer's Research Australia, Sarich Neuroscience Research Institute Nedlands Western Australia Australia.; School of Psychological Science University of Western Australia Perth Western Australia Australia.; School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2024 Apr 22; Vol. 16 (2), pp. e12579. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).
DOI: 10.1002/dad2.12579
Abstrakt: Introduction: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.
Methods: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3-72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E ( APOE ) ε4 allele status, and time, adjusting for sex and baseline age.
Results: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ.
Discussion: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.
Highlights: In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.Across sleep characteristics, this relationship differs by apolipoprotein E ( APOE ) genotype.Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.Personalized sleep interventions should be studied for potential to slow Aβ accumulation.
Competing Interests: L.N.P., B.M.B., K.R.S., J.D.D., V.D., M.W., H.R.S., S.L.G., R.S.B., S.M.L., K.T., and S.R.R.S. report no disclosures. V.L.V. is and has been a consultant or paid speaker at sponsored conference sessions for Eli Lilly, Life Molecular Imaging, ACE Barcelona, and IXICO. P.M. is a full‐time employee of Cogstate Ltd. C.L.M. is an advisor to Prana Biotechnology Ltd and a consultant to Eli Lilly. C.C.R. has served on scientific advisory boards for Bayer Pharma, Elan Corporation, GE Healthcare, and AstraZeneca; has received speaker honoraria from Bayer Pharma and GE Healthcare; and has received research support from Bayer Pharma, GE Healthcare, Piramal Lifesciences, and Avid Radiopharmaceuticals. R.N.M. is founder of, and owns stock in, Alzhyme, and is a co‐founder of the KaRa Institute of Neurological Diseases. Author disclosures are available in the supporting information
(© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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