Chitosan-graphene quantum dot based active film as smart wound dressing.

Autor: Ribeiro ERFR; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil., Correa LB; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil., Ricci-Junior E; Federal University of Rio de Janeiro, School of Pharmacy, Galenic Development Laboratory (LADEG), Rio de Janeiro, 21941-170, Brazil., Souza PFN; Biochemistry and Molecular Biology Department, Federal University of Ceará, CE, Brazil, Laboratory of Plant Defense Proteins, Ceará, 60451, Brazil.; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal, University of Ceará, 60451, Brazil., Dos Santos CC; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil., de Menezes AS; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil., Rosas EC; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil.; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil., Bhattarai P; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA., Attia MF; Center for Nanotechnology in Drug Delivery and Division of Pharmaco-engineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Zhu L; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA., Alencar LMR; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.; State University of Rio de Janeiro, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro, 23070200, Brazil.
Jazyk: angličtina
Zdroj: Journal of drug delivery science and technology [J Drug Deliv Sci Technol] 2023 Feb; Vol. 80. Date of Electronic Publication: 2022 Dec 22.
DOI: 10.1016/j.jddst.2022.104093
Abstrakt: Graphene quantum dots (GQDs), are biocompatible materials, with mechanical strength and stability. Chitosan, has antibacterial and anti-inflammatory properties, and biocompatibility. Wound healing is a challenging process especially in chronic diseases and infection. In this study, films consisting of chitosan and graphene quantum dots were developed for application in infected wounds. The chitosan-graphene films were prepared in the acidic solution followed by slow solvent evaporation and drying. The chitosan-graphene films were characterized by the scanning electron microscopy, x-ray diffraction, atomic force microscopy, Raman spectroscopy and thermogravimetric analysis. The films' was evaluated by the wound healing assays, hemolytic potential, and nitrite production, cytokine production and swelling potential. The obtained films were flexible and well-structured, promoting cell migration, greater antibacterial activity, lower hemolytic activity, and maintaining wound moisture. Our data suggested that the use of graphene quantum dot-containing chitosan films would be an efficient and promising way in combating wounds.
Competing Interests: Declaration of competing interest The authors have declared no conflict of interest.
Databáze: MEDLINE
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