Characteristics of Different Obesity Metabolic Indexes and their Correlation with Insulin Resistance in Patients with Polycystic Ovary Syndrome.
Autor: | Feng Y; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Li M; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Li X; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Tang Q; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Li X; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Ji X; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Tian W; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China., Zhang H; Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, NO 154, Anshan Road, Tianjin, He Ping District, 300052, People's Republic of China. huiying_zhang2020@126.com. |
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Jazyk: | angličtina |
Zdroj: | Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Apr 22. Date of Electronic Publication: 2024 Apr 22. |
DOI: | 10.1007/s43032-024-01532-9 |
Abstrakt: | This study is aimed to investigate the characteristics of different obesity metabolic indexes [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), cardiometabolic index (CMI), body roundness index (BRI), visceral adiposity index (VAI), and lipid aggregation products (LAP)] and their correlation with insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS). The study was conducted on 140 subjects with PCOS and 133 control subjects aged 18-44 years. According to insulin resistance index (HOMA-IR) ≥ 2.69 and HOMA-IR < 2.69, PCOS group members were divided into insulin resistance group and non-insulin resistance group. Anthropometric and serological characteristics of the population with PCOS focused on calculating different obesity metabolic indexes and HOMA-IR. BMI, WC, WHR, WHtR, CMI, BRI, VAI, and LAP were significantly higher in PCOS patients than in the control group, and the differences were all statistically significant (P < 0.05); In the insulin resistance group of PCOS patients, BMI, WC, WHR, WHtR, CMI, BRI, VAI, and LAP were significantly higher than in the non-insulin resistance group (P < 0.05). In PCOS patients, BMI (r = 0.658, P < 0.001), WC (r = 0.0.662, P < 0.001), WHR (r = 0.377, P < 0.001), WHtR (r = 0.660, P < 0.001), CMI (r = 0.698, P < 0.001), BRI (r = 0.757, P < 0.001), VAI (r = 0.640, P < 0.001), and LAP (r = 0.767, P < 0.001) were positively correlated with IR. Obesity metabolic indexes associated with PCOS were elevated in the PCOS group compared to the control group, and in the PCOS insulin-resistant group compared to the non-insulin resistant group. Novel obesity metabolic indexes, especially CMI, BRI and LAP, might be more appropriate for evaluating the risk of concurrent IR in PCOS. (© 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.) |
Databáze: | MEDLINE |
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