Photobiomodulation in promoting increased Skin Flap Viability: a systematic review of animal studies.

Autor: Chang AJBA; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., de Barros Pinto EAF; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., Silva DR; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., David AC; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., de Matos LP; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., Marcos RL; Postgraduate Program in Medicine Biophotonics, Universidade Nove de Julho, Rua Vergueiro, 235, Liberdade, 01504-000, São Paulo, Brasil., Silva Junior JA; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil., Zamuner SR; Postgraduate Program in Medicine, Universidade Nove de Julho, UNINOVE, Rua Vergueiro, 234, Bairro Liberdade, 01504-000, São Paulo, Brasil. stella.rz@uni9.pro.br.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2024 Apr 22; Vol. 39 (1), pp. 109. Date of Electronic Publication: 2024 Apr 22.
DOI: 10.1007/s10103-024-04055-6
Abstrakt: Necrosis is common in skin flap surgeries. Photobiomodulation, a noninvasive and effective technique, holds the potential to enhance microcirculation and neovascularization. As such, it has emerged as a viable approach for mitigating the occurrence of skin flap necrosis. The aim of this systematic review was to examine the scientific literature considering the use of photobiomodulation to increase skin-flap viability. The preferred reporting items for systematic reviews and meta-analyses (PRISMA), was used to conducted systematic literature search in the databases PubMed, SCOPUS, Elsevier and, Scielo on June 2023. Included studies investigated skin-flap necrosis employing PBMT irradiation as a treatment and, at least one quantitative measure of skin-flap necrosis in any animal model. Twenty-five studies were selected from 54 original articles that addressed PBMT with low-level laser (LLL) or light-emitting diode (LED) in agreement with the qualifying requirements. Laser parameters varied markedly across studies. In the selected studies, the low-level laser in the visible red spectrum was the most frequently utilized PBMT, although the LED PBMT showed a similar improvement in skin-flap necrosis. Ninety percent of the studies assessing the outcomes of the effects of PBMT reported smaller areas of necrosis in skin flap. Studies have consistently demonstrated the ability of PBMT to improve skin flap viability in animal models. Evidence suggests that PBMT, through enhancing angiogenesis, vascular density, mast cells, and VEGF, is an effective therapy for decrease necrotic tissue in skin flap surgery.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
Databáze: MEDLINE
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