Chiral-induced synthesis of chiral covalent organic frameworks core-shell microspheres for HPLC enantioseparation.

Autor: Liu C; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China., Guo P; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China., Ran XY; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China., Zhu YL; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China., Wang BJ; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China., Zhang JH; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China. zjh19861202@126.com., Xie SM; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China. xieshengming_2006@163.com., Yuan LM; Department of Chemistry, Yunnan Normal University, Kunming, 650500, People's Republic of China.
Jazyk: angličtina
Zdroj: Mikrochimica acta [Mikrochim Acta] 2024 Apr 23; Vol. 191 (5), pp. 281. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1007/s00604-024-06347-8
Abstrakt: Two chiral covalent organic frameworks (CCOFs) core-shell microspheres based on achiral organic precursors by chiral-induced synthesis strategy for HPLC enantioseparation are reported for the first time. Using n-hexane/isopropanol as mobile phase, various kinds of racemates were selected as analytes and separated on the CCOF-TpPa-1@SiO 2 and CCOF-TpBD@SiO 2 -packed columns with a low column backpressure (3 ~ 9 bar). The fabricated two CCOFs@SiO 2 chiral columns exhibited good separation performance towards various racemates with high column efficiency (e.g., 19,500 plates m -1 for (4-fluorophenyl)ethanol and 18,900 plates m -1 for 1-(4-chlorophenyl)ethanol) and good reproducibility. Some effects have been investigated such as the analyte mass and column temperature on the HPLC enantioseparation. Moreover, the chiral separation results of the CCOF-TpPa-1@SiO 2 chiral column and the commercialized Chiralpak AD-H column show a good complementarity. This study demonstrates that the usage of chiral-induced synthesis strategy for preparing CCOFs core-shell microspheres as a novel stationary phase has a good application potential in HPLC.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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