QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model.
Autor: | Ramireddy AR; Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, 515002, India. amarpharmacy123@gmail.com., Behara DK; Chemical Engineering, JNTUA College of Engineering (Autonomous), Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, 515002, India. |
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Jazyk: | angličtina |
Zdroj: | AAPS PharmSciTech [AAPS PharmSciTech] 2024 Apr 22; Vol. 25 (5), pp. 90. Date of Electronic Publication: 2024 Apr 22. |
DOI: | 10.1208/s12249-024-02805-x |
Abstrakt: | To formulate and optimize Ozenoxacin nano-emulsion using Quality by Design (QbD) concept by means of Box-Behnken Design (BBD) and converting it to a gel to form Ozenoxacin nano-emulgel followed by physico-chemical, in-vitro, ex-vivo and in-vivo evaluation. This study demonstrates the application of QbD methodology for the development and optimization of an effective topical nanoemulgel formulation for the treatment of Impetigo focusing on the selection of appropriate excipients, optimization of formulation and process variables, and characterization of critical quality attributes. BBD was used to study the effect of "% of oil, % of S (© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.) |
Databáze: | MEDLINE |
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