Anorectal malformation and Hirschsprung's disease: a cross-sectional multicentre comparison of quality of life and bowel function to a healthy population.

Autor:	Rajasegaran S; Department of Surgery, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia., Ahmad NA; Department of Paediatric Surgery, Sabah Women and Children's Hospital, Kota Kinabalu, Sabah, Malaysia., Tan SK; Paediatric Surgery Unit, Department of Surgery, Hospital Sultanah Bahiyah, Alor Setar, Kedah Darul Aman, Malaysia., Lechmiannandan A; Department of Paediatric Surgery, Women's and Children's Hospital Kuala Lumpur, Hospital Tunku Azizah, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Mohamed OM; Department of Surgery, University Malaya Medical Center, Kuala Lumpur, Kuala Lumpur, Malaysia., Cheng JQ; Paediatric Surgery Unit, Department of Surgery, Hospital Sultanah Bahiyah, Alor Setar, Kedah Darul Aman, Malaysia., Hassan J; Paediatric Surgery Unit, Department of Surgery, Hospital Sultanah Bahiyah, Alor Setar, Kedah Darul Aman, Malaysia., Sanmugam A; Department of Surgery, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia.; Department of Surgery, University Malaya Medical Center, Kuala Lumpur, Kuala Lumpur, Malaysia., Singaravel S; Department of Surgery, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia.; Department of Surgery, University Malaya Medical Center, Kuala Lumpur, Kuala Lumpur, Malaysia., Mohd Khalid H; Department of Paediatric Surgery, Sabah Women and Children's Hospital, Kota Kinabalu, Sabah, Malaysia., Abdullah MY; Department of Paediatric Surgery, Women's and Children's Hospital Kuala Lumpur, Hospital Tunku Azizah, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia., Nah SA; Department of Surgery, University of Malaya, Kuala Lumpur, Wilayah Persekutuan, Malaysia shireen.nah@ummc.edu.my.; Department of Surgery, University Malaya Medical Center, Kuala Lumpur, Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood [Arch Dis Child] 2024 Jun 19; Vol. 109 (7), pp. 557-562. Date of Electronic Publication: 2024 Jun 19.
DOI:	10.1136/archdischild-2023-326724
Abstrakt:	Purpose: Children with anorectal malformation (ARM) and Hirschsprung's disease (HD) often experience bowel symptoms into adulthood, despite definitive surgery. This study evaluates the quality of life (QOL) and bowel functional outcome of children treated for ARM and HD in comparison to healthy controls. Methods: Between December 2020 and February 2023, we recruited patients with ARM and HD aged 3-17 years at four tertiary referral centres, who had primary corrective surgery done >12 months prior. Healthy controls were age-matched and sex-matched. All participants completed the Pediatric Quality of Life Inventory Generic Core Scales 4.0, General Well-Being (GWB) Scale 3.0 and Family Impact (FI) Module 2.0 Questionnaires. Bowel Function Score (BFS) Questionnaires were also administered. We also performed subgroup analysis according to age categories. Appropriate statistical analysis was performed with p<0.05 significance. Ethical approval was obtained. Results: There were 306 participants: 101 ARM, 87 HD, 118 controls. Patients with ARM and HD had significantly worse Core and FI Scores compared with controls overall and in all age categories. In the GWB Scale, only ARM and HD adolescents (13-17 years) had worse scores than controls. ARM and HD had significantly worse BFSs compared with controls overall and in all age categories. There was significant positive correlation between BFS and Core Scores, GWB Scores and FI Scores. Conclusion: Patients with ARM and HD had worse QOL than controls. Lower GWB Scores in adolescents suggests targeted interventions are necessary. Bowel function influences QOL, indicating the need for continuous support into adulthood. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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