Long-term exposure to air pollution and chronic kidney disease-associated mortality-Results from the pooled cohort of the European multicentre ELAPSE-study.

Autor: Kadelbach P; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany. Electronic address: pauline.kadelbach@uni-ulm.de., Weinmayr G; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany. Electronic address: gudrun.weinmayr@uni-ulm.de., Chen J; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Jaensch A; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany., Rodopoulou S; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Strak M; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment, Bilthoven, the Netherlands., de Hoogh K; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland., Andersen ZJ; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Bellander T; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden., Brandt J; Department of Environmental Science, Aarhus University, Roskilde, Denmark; iClimate-interdisciplinary Centre for Climate Change, Aarhus University, Roskilde, Denmark., Cesaroni G; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy., Fecht D; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Forastiere F; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy; Environmental Research Group, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom., Gulliver J; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, United Kingdom., Hertel O; Faculty of Technical Sciences, Aarhus University, Roskilde, Denmark., Hoffmann B; Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Hvidtfeldt UA; The Danish Cancer Institute, Copenhagen, Denmark., Katsouyanni K; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Ketzel M; Department of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, GU2 7XH, United Kingdom., Leander K; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden., Ljungman P; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Department of Cardiology, Danderyd University Hospital, 182 88, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pershagen G; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden., Rizzuto D; Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden., Samoli E; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Severi G; University Paris-Saclay, UVSQ, Inserm, Gustave Roussy, 'Exposome and Heredity' team, CESP UMR1018, 94805, Villejuif, France., Stafoggia M; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy., Tjønneland A; Department of Public Health, University of Copenhagen, Copenhagen, Denmark; The Danish Cancer Institute, Copenhagen, Denmark., Vermeulen R; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Wolf K; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Raaschou-Nielsen O; Department of Environmental Science, Aarhus University, Roskilde, Denmark; The Danish Cancer Institute, Copenhagen, Denmark., Brunekreef B; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Hoek G; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Zitt E; Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria; Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria., Nagel G; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany; Agency for Preventive and Social Medicine (aks), Bregenz, Austria.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Jul 01; Vol. 252 (Pt 3), pp. 118942. Date of Electronic Publication: 2024 Apr 20.
DOI: 10.1016/j.envres.2024.118942
Abstrakt: Despite the known link between air pollution and cause-specific mortality, its relation to chronic kidney disease (CKD)-associated mortality is understudied. Therefore, we investigated the association between long-term exposure to air pollution and CKD-related mortality in a large multicentre population-based European cohort. Cohort data were linked to local mortality registry data. CKD-death was defined as ICD10 codes N18-N19 or corresponding ICD9 codes. Mean annual exposure at participant's home address was determined with fine spatial resolution exposure models for nitrogen dioxide (NO 2 ), black carbon (BC), ozone (O 3 ), particulate matter ≤2.5 μm (PM 2.5 ) and several elemental constituents of PM 2.5 . Cox regression models were adjusted for age, sex, cohort, calendar year of recruitment, smoking status, marital status, employment status and neighbourhood mean income. Over a mean follow-up time of 20.4 years, 313 of 289,564 persons died from CKD. Associations were positive for PM 2.5 (hazard ratio (HR) with 95% confidence interval (CI) of 1.31 (1.03-1.66) per 5 μg/m 3 , BC (1.26 (1.03-1.53) per 0.5 × 10 - 5 /m), NO 2 (1.13 (0.93-1.38) per 10 μg/m 3 ) and inverse for O 3 (0.71 (0.54-0.93) per 10 μg/m 3 ). Results were robust to further covariate adjustment. Exclusion of the largest sub-cohort contributing 226 cases, led to null associations. Among the elemental constituents, Cu, Fe, K, Ni, S and Zn, representing different sources including traffic, biomass and oil burning and secondary pollutants, were associated with CKD-related mortality. In conclusion, our results suggest an association between air pollution from different sources and CKD-related mortality.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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