PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis.

Autor:	Geng Q; China-Japan Friendship Clinical Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100029, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China., Xu J; Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100029, China., Cao X; China-Japan Friendship Clinical Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100029, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China., Wang Z; China-Japan Friendship Clinical Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100029, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China., Jiao Y; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China; Beijing University of Chinese Medicine, China-Japan Friendship Hospital Clinical Medicine, Beijing, 100029, China., Diao W; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China; Beijing University of Chinese Medicine, China-Japan Friendship Hospital Clinical Medicine, Beijing, 100029, China., Wang X; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China; Beijing University of Chinese Medicine, China-Japan Friendship Hospital Clinical Medicine, Beijing, 100029, China., Wang Z; Beijing University of Chinese Medicine, China-Japan Friendship Hospital Clinical Medicine, Beijing, 100029, China; Department of TCM Rheumatology, China-Japan Friendship Hospital, Beijing, 100029, China., Zhang M; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China., Zhao L; China-Japan Friendship Hospital, Capital Medical University, Beijing, 100029, China., Yang L; Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China., Deng T; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China., Fan B; Department of Pain Management, China-Japan Friendship Hospital, Beijing, 100029, China., Xu Y; Department of TCM Rheumatology, China-Japan Friendship Hospital, Beijing, 100029, China., Jia L; Department of Anorectal, China-Japan Friendship Hospital, Beijing, 100029, China. Electronic address: alfarabyyy@126.com., Xiao C; China-Japan Friendship Clinical Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100029, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China; Department of Emergency, China-Japan Friendship Hospital, Beijing, 100029, China. Electronic address: xc2002812@126.com.
Jazyk:	angličtina
Zdroj:	Journal of autoimmunity [J Autoimmun] 2024 Jun; Vol. 146, pp. 103214. Date of Electronic Publication: 2024 Apr 21.
DOI:	10.1016/j.jaut.2024.103214
Abstrakt:	Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint inflammation and bone damage, that not only restricts patient activity but also tends to be accompanied by a series of complications, seriously affecting patient prognosis. Peroxisome proliferator-activated receptor gamma (PPARG), a receptor that controls cellular metabolism, regulates the function of immune cells and stromal cells. Previous studies have shown that PPARG is closely related to the regulation of inflammation. However, the role of PPARG in regulating the pathological processes of RA is poorly understood. Materials and Methods: PPARG expression was examined in the synovial tissues and peripheral blood mononuclear cells (PBMCs) from RA patients and the paw of collagen-induced arthritis (CIA) model rats. Molecular biology experiments were designed to examine the effect of PPARG and cannabidiol (CBD) on RAW264.7 cells and CIA rats. Results: The results reveal that PPARG accelerates reactive oxygen species (ROS) clearance by promoting autophagy, thereby inhibiting ROS-mediated macrophage polarization and NLRP3 inflammasome activation. Notably, CBD may be a promising candidate for understanding the mechanism by which PPARG regulates autophagy-mediated inflammation. Conclusions: Taken together, these findings indicate that PPARG may have a role for distinguishing between RA patients and healthy control, and for distinguishing RA activity; moreover, PPARG could be a novel pharmacological target for alleviating RA through the mediation of autophagy. CBD can act as a PPARG agonist that alleviates the inflammatory progression of RA. Competing Interests: Declaration of Competing interest The authors declare that they have no conflicts of interest. (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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