Temperature-driven coordination of circadian transcriptional regulation.

Autor: Xu B; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America.; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, United States of America., Hwangbo DS; Department of Biology, University of Louisville, Louisville, Kentucky, United States of America.; Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America., Saurabh S; Department of Biology, Loyola University, Chicago, Illinois, United States of America., Rosensweig C; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, United States of America.; Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America., Allada R; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, United States of America.; Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, United States of America.; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America., Kath WL; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, United States of America.; Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America.; Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois, United States of America.; Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America., Braun R; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America.; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, United States of America.; Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois, United States of America.; Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America.; Department of Physics and Astronomy, Northwestern University, Evanston, Illinois, United States of America.; Santa Fe Institute, Santa Fe, New Mexico, United States of America.
Jazyk: angličtina
Zdroj: PLoS computational biology [PLoS Comput Biol] 2024 Apr 22; Vol. 20 (4), pp. e1012029. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).
DOI: 10.1371/journal.pcbi.1012029
Abstrakt: The circadian clock is an evolutionarily-conserved molecular oscillator that enables species to anticipate rhythmic changes in their environment. At a molecular level, the core clock genes induce circadian oscillations in thousands of genes in a tissue-specific manner, orchestrating myriad biological processes. While previous studies have investigated how the core clock circuit responds to environmental perturbations such as temperature, the downstream effects of such perturbations on circadian regulation remain poorly understood. By analyzing bulk-RNA sequencing of Drosophila fat bodies harvested from flies subjected to different environmental conditions, we demonstrate a highly condition-specific circadian transcriptome: genes are cycling in a temperature-specific manner, and the distributions of their phases also differ between the two conditions. Further employing a reference-based gene regulatory network (Reactome), we find evidence of increased gene-gene coordination at low temperatures and synchronization of rhythmic genes that are network neighbors. We report that the phase differences between cycling genes increase as a function of geodesic distance in the low temperature condition, suggesting increased coordination of cycling on the gene regulatory network. Our results suggest a potential mechanism whereby the circadian clock mediates the fly's response to seasonal changes in temperature.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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