Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study.

Autor:	Shahbazi Khamas S; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Van Dijk Y; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Abdel-Aziz MI; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Neerincx AH; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Maarten Blankestijn J; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Vijverberg SJH; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Hashimoto S; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Bush A; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton Hospital, London, United Kingdom., Kraneveld AD; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Hedman AM; Department of Medical Epidemiology and Biostatistics., Toncheva AA; Department of Pediatric Pneumology and Allergy and., Almqvist C; Department of Medical Epidemiology and Biostatistics.; Pediatric Allergy and Pulmonology Unit., Wolff C; Science and Development Campus Regensburg, University Children's Hospital Regensburg, Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany., Murray CS; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre and National Institute for Health and Care Research Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom., Hedlin G; Department of Women's and Children's Health, and.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Roberts G; National Institute for Health and Care Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Clinical and Experimental Sciences and Human Development and Health, University of Southampton, Southampton, United Kingdom., Adcock IM; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton Hospital, London, United Kingdom., Korta-Murua J; Division of Pediatric Respiratory Medicine, Donostia University Hospital, San Sebastián, Spain., Bønnelykke K; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Fleming LJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Royal Brompton Hospital, London, United Kingdom., Pino-Yanes M; Institute of Biomedical Technologies and.; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, University of La Laguna, La Laguna, Spain.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain., Gorenjak M; Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, and., Kabesch M; Department of Pediatric Pneumology and Allergy and.; Science and Development Campus Regensburg, University Children's Hospital Regensburg, Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany., Sardón-Prado O; Division of Pediatric Respiratory Medicine, Donostia University Hospital, San Sebastián, Spain.; Department of Pediatrics, University of the Basque Country, San Sebastián, Spain., Montuschi P; Department of Pharmacology, Catholic University of the Sacred Heart, and Agostino Gemelli University Hospital Foundation, IRCCS, Rome, Italy., Singer F; Division of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Elosegui PC; Division of Pediatric Respiratory Medicine, Donostia University Hospital, San Sebastián, Spain., Fowler SJ; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre and National Institute for Health and Care Research Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom., Brandstetter S; Science and Development Campus Regensburg, University Children's Hospital Regensburg, Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany., Harner S; Department of Pediatric Pneumology and Allergy and., Dahlén SE; Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institute, Stockholm, Sweden., Potočnik U; Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, and.; Laboratory for Biochemistry, Molecular Biology and Genomics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia.; Department for Science and Research, University Medical Centre Maribor, Maribor, Slovenia; and., Frey U; University Children's Hospital Basel, University of Basel, Basel, Switzerland., van Aalderen W; Amsterdam Public Health, Amsterdam, the Netherlands., Brinkman P; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands., Maitland-van der Zee AH; Department of Pulmonary Medicine and.; Department of Paediatric Pulmonary Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.; Amsterdam Public Health, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Nov 01; Vol. 210 (9), pp. 1091-1100.
DOI:	10.1164/rccm.202312-2270OC
Abstrakt:	Rationale: The early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. Objectives: To assess the accuracy of gas chromatography-mass spectrometry-based exhaled metabolite analysis to differentiate between controlled and uncontrolled pediatric asthma. Methods: This study encompassed discovery (SysPharmPediA [Systems Pharmacology Approach to Uncontrolled Paediatric Asthma]) and validation (U-BIOPRED [Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes] and PANDA [Paediatric-Asthma-Non-Invasive-Diagnostic-Approaches]) phases. First, exhaled VOCs that discriminated degrees of asthma control were identified. Subsequently, outcomes were validated in two independent cohorts. Patients were classified as controlled or uncontrolled on the basis of asthma control test scores and the number of severe attacks in the past year. In addition, the potential of VOCs to predict two or more future severe asthma attacks in SysPharmPediA was evaluated. Measurements and Main Results: Complete data were available for 196 children (SysPharmPediA, n  = 100; U-BIOPRED, n  = 49; PANDA, n  = 47). In SysPharmPediA, after randomly splitting the population into training ( n  = 51) and test ( n  = 49) sets, three compounds (acetophenone, ethylbenzene, and styrene) distinguished between patients with uncontrolled and controlled asthma. The areas under the receiver operating characteristic curves (AUROCCs) for training and test sets were, respectively, 0.83 (95% confidence interval [CI], 0.65-1.00) and 0.77 (95% CI, 0.58-0.96). Combinations of these VOCs resulted in AUROCCs of 0.74 ± 0.06 (U-BIOPRED) and 0.68 ± 0.05 (PANDA). Attack prediction tests resulted in AUROCCs of 0.71 (95% CI, 0.51-0.91) and 0.71 (95% CI, 0.52-0.90) for the training and test sets. Conclusions: Exhaled metabolite analysis might enable asthma control classification in children. This should stimulate the further development of exhaled metabolite-based point-of-care tests in asthma.
Databáze:	MEDLINE
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