Influence of GABA A and GABA B receptor activation on auditory sensory gating and its association with anxiety in healthy volunteers.

Autor: de la Salle S; The Royal's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.; School of Psychology, University of Ottawa, Ottawa, ON, Canada., Piche J; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Duncan B; Department of Psychology, Carleton University, Ottawa, ON, Canada., Choueiry J; The Royal's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Hyde M; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Aidelbaum R; School of Psychology, University of Toronto, Toronto, ON, Canada., Baddeley A; The Royal's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada., Impey D; School of Psychology, University of Ottawa, Ottawa, ON, Canada., Rahmani N; School of Psychology, University of Ottawa, Ottawa, ON, Canada., Ilivitsky V; The Royal Ottawa Mental Health Centre, Ottawa, ON, Canada., Knott V; The Royal's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Jazyk: angličtina
Zdroj: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2024 Jun; Vol. 38 (6), pp. 532-540. Date of Electronic Publication: 2024 Apr 22.
DOI: 10.1177/02698811241246854
Abstrakt: Background: Dysfunctional sensory gating in anxiety disorders, indexed by the failure to inhibit the P50 event-related potential (ERP) to repeated stimuli, has been linked to deficits in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Aims/methods: This study, conducted in 30 healthy volunteers, examined the acute effects of GABA A (lorazepam: 1 mg) and GABA B receptor (baclofen: 10 mg) agonists on P50 measures of auditory sensory gating within a paired-stimulus (S1-S2) paradigm and assessed changes in gating in relation to self-ratings of anxiety.
Results: Compared to placebo, lorazepam reduced ERP indices of sensory gating by attenuating response to S1. Although not directly impacting P50 inhibition, baclofen-induced changes in gating (relative to placebo) were negatively correlated with trait but not state anxiety.
Conclusions: These preliminary findings support the involvement of GABA in sensory gating and tentatively suggest a role for GABA B receptor signaling in anxiety-associated gating dysregulation.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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