Living Beyond Restriction: LBR promotes cellular immortalization by suppressing genomic instability and senescence.

Autor: Choi H; School of Biological Sciences, Seoul National University, South Korea.; Center for Systems Geroscience, Seoul National University, South Korea., Kang C; School of Biological Sciences, Seoul National University, South Korea.; Center for Systems Geroscience, Seoul National University, South Korea.
Jazyk: angličtina
Zdroj: The FEBS journal [FEBS J] 2024 May; Vol. 291 (10), pp. 2091-2093. Date of Electronic Publication: 2024 Apr 22.
DOI: 10.1111/febs.17141
Abstrakt: Cellular immortalization is a complex process that requires multiple genetic alterations to overcome restricting barriers, including senescence. Not surprisingly, many of these alterations are associated with cancer; two tumor suppressor pathways, the cellular tumor antigen p53 and p16-Retinoblastoma (RB) pathways, are the best-characterized examples, but their mutations alone are known to be insufficient to drive full immortalization. En et al. identified a role for the lamin B receptor (LBR) in promoting cellular proliferation and immortalization in p53- and RB-deficient cells by maintaining their genome integrity and suppressing senescence. Thus, modulation of LBR could be exploited to treat cancer and potentially also to promote cell rejuvenation.
(© 2024 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
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