Oral cancer in young adults: should we approach these patients differently?

Autor:	Szewczyk M; Department of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Center, Poznań, Poland., Pazdrowski J; Department of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Center, Poznań, Poland., Golusiński P; Department of Otolaryngology and Maxillofacial Surgery, University of Zielona Góra, Zielona Góra, Poland., Więckowska B; Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland., Golusiński W; Department of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Center, Poznań, Poland.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Apr 05; Vol. 14, pp. 1297752. Date of Electronic Publication: 2024 Apr 05 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1297752
Abstrakt:	Objective: The influence of age on treatment outcomes in oral cancer is unclear. We aimed to determine the prevalence of oral cancer in adults under age 45 and to compare treatment outcomes by age. Methods: Retrospective study of 284 patients treated for oral cancer from 2010 to 2021. The primary analysis involved the full cohort stratified by age (< vs. ≥ 45y). The second analysis included all patients under age 45 (n=44) matched 1:1 by sex and stage to older patients (age 55-70). Results: In the primary analysis, the only significant difference was more comorbidities in the older group (p<0.001). In the matched-pair analysis, older patients were more likely to be smokers (75% vs. 54%; p=0.045) and had more comorbidities (p=0.007). The mean PLR and NLR values were significantly higher in the younger group. Conclusions: No significant differences were observed between age groups in disease stage or outcomes, suggesting that other variables are more important. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Szewczyk, Pazdrowski, Golusiński, Więckowska and Golusiński.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu