Medication-related osteonecrosis of the jaw: Case series and literature review.

Autor: Kimathi D; Oral and Maxillofacial Department University of Nairobi Nairobi Kenya., Butt F; Human Anatomy Department University of Nairobi Nairobi Kenya., Guthua S; Oral and Maxillofacial Department University of Nairobi Nairobi Kenya., Waweru W; Human Pathology Department University of Nairobi Nairobi Kenya.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2024 Apr 20; Vol. 12 (4), pp. e8788. Date of Electronic Publication: 2024 Apr 20 (Print Publication: 2024).
DOI: 10.1002/ccr3.8788
Abstrakt: Key Clinical Message: Medication-related osteonecrosis of the Jaw (MRONJ) is a rare complication of the jaws following the administration of antiresorptive or antiangiogenic drugs. This condition poses a major challenge to its management. Its prevention and management need a multidisciplinary collaboration. We described three patients with MRONJ including their presentation, investigations, management protocols, and outcomes. A brief appraisal of the literature on MRONJ was also done.
Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of the jaws following the administration of antiresorptive or antiangiogenic drugs. This condition poses a major challenge to its management. We present an appraisal of the literature and three cases of MRONJ. An appraisal of 3 patients who presented to the oral and maxillofacial clinic with MRONJ was done. Relevant physical examination findings, radiological images, clinical photographs and follow-up was documented. One patient had multiple myeloma while the other two had metastatic cancer. All had received zoledronic acid before developing MRONJ. One patient was surgically treated and successfully recovered while two were managed conservatively. Patients taking antiresorptive medications are at risk of developing MRONJ. Prevention and management of the condition calls for a multidisciplinary collaboration. Patients taking antiresorptive medications need good education on the risks associated with the medications and how to recognize early signs and symptoms.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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