Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries.

Autor:	Griswold AJ; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA., Rajabli F; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA., Gu T; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Arvizu J; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Golightly CG; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Whitehead PL; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Adams LD; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Sanchez JJ; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Mena PR; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Starks TD; Maya Angelou Center for Health Equity, Wake Forest University, Winston-Salem, NC, 27102, USA., Illanes-Manrique M; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, 15003, Peru., Silva C; Department of Internal Medicine, Universidad Central Del Caribe, Bayamón, Puerto Rico, 00960, USA., Bush WS; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.; Cleveland Institute for Computational Biology, Cleveland, OH, 44106, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA., Cornejo-Olivas MR; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, 15003, Peru., Feliciano-Astacio BE; Department of Internal Medicine, Universidad Central Del Caribe, Bayamón, Puerto Rico, 00960, USA., Byrd GS; Maya Angelou Center for Health Equity, Wake Forest University, Winston-Salem, NC, 27102, USA., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA., Haines JL; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.; Cleveland Institute for Computational Biology, Cleveland, OH, 44106, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA.; Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, 33136, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 12. Date of Electronic Publication: 2024 Apr 12.
DOI:	10.1101/2024.04.10.24305617
Abstrakt:	Introduction: Plasma phosphorylated threonine-181 of Tau and amyloid beta are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). Given differences in AD risk across diverse populations, generalizability of existing biomarker data is not assured. Methods: In 2,086 individuals of diverse genetic ancestries (African American, Caribbean Hispanic, and Peruvians) we measured plasma pTau-181 and Aβ42/Aβ40. Differences in biomarkers between cohorts and clinical diagnosis groups and the potential discriminative performance of the two biomarkers were assessed. Results: pTau-181 and Aβ42/Aβ40 were consistent across cohorts. Higher levels of pTau181 were associated with AD while Aβ42/Aβ40 had minimal differences. Correspondingly, pTau-181 had greater predictive value than Aβ42/Aβ40, however, the area under the curve differed between cohorts. Discussion: pTau-181 as a plasma biomarker for clinical AD is generalizable across genetic ancestries, but predictive value may differ. Combining genomic and biomarker data from diverse individuals will increase understanding of genetic risk and refine clinical diagnoses. Competing Interests: Conflict of Interest The authors declare no conflicts of interest.
Databáze:	MEDLINE
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