Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study.

Autor: de Sire A; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Marotta N; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Physical and Rehabilitative Medicine Unit, Department of Experimental and Clinical Medicine, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Sconza C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Milan, Italy., Lippi L; Department of Scientific Research, Campus LUdeS Lugano (CH), Off-Campus Semmelweis University of Budapest, Budapest, Hungary., Drago Ferrante V; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Respizzi S; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Milan, Italy., Invernizzi M; Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.; Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Translational Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Ammendolia A; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Disability and rehabilitation [Disabil Rehabil] 2024 Apr 21, pp. 1-7. Date of Electronic Publication: 2024 Apr 21.
DOI: 10.1080/09638288.2024.2342491
Abstrakt: Purpose: Trapeziometacarpal osteoarthritis (TMC-OA) is a prevalent hand disorder affecting a growing number of people worldwide. While a multidisciplinary approach might provide additional advantages, the analgesic and anti-inflammatory role of intra-articular oxygen-ozone (O 2 O 3 ) injections combined with physical therapy is still unknown. To assess the impact of a multimodal therapeutic approach combining O 2 O 3 injections with physical therapy in patients with TMC-OA.
Materials and Methods: A prospective open-label study conducted in the Physical and Rehabilitation Medicine Unit of the "Renato Dulbecco" University Hospital of Catanzaro. We assessed patients with TMC-OA who had not responded to standard medical therapy. Participants received O 2 O 3 therapy and targeted physical therapy for 4 weeks. Pain relief, muscle strength, and physical functioning were assessed at baseline and after 4, 12 and 24 weeks (respectively T0, T1, T2, and T3).
Results: Seventeen patients with a mean age of 67.1 ± 6.1 years were included in the study. Short-term improvements in pain intensity were observed (T0: 6.221 ± 1.514; T1: 3.172 ± 1.1451; p < .001) and were maintained over a 24-week follow-up period (T0: 6.221 ± 1.514; T3: 4.393 ± 1.438; p : 0.006). Significant changes were reported also in terms of muscle strength and physical functioning. O 2 O 3 therapy was well-tolerated with no adverse effects.
Conclusions: A combination of O 2 O 3 injections and physical therapy might be considered in patients with TMC-OA. Further investigation is warranted to assess the effectiveness of O 2 O 3 therapy in managing TMC-OA.
Databáze: MEDLINE
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