Kisspeptin administration may promote precopulatory behavior in male rats independently or supplementally to testosterone and contribute to proceptive behavior in female partners, reducing mating failure.

Autor: Yamamoto S; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan; Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-0808, Japan., Arakaki R; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Noguchi H; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Takeda A; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Uchishiba M; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Kamada S; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Mineda A; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Kon M; Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-0808, Japan., Kinouchi R; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Yamamoto Y; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Yoshida K; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Kaji T; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan., Shinohara N; Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-0808, Japan., Iwasa T; Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Graduate School, Tokushima University, Tokushima 770-8501, Japan. Electronic address: iwasa.takeshi@tokushima-u.ac.jp.
Jazyk: angličtina
Zdroj: General and comparative endocrinology [Gen Comp Endocrinol] 2024 Jul 01; Vol. 353, pp. 114528. Date of Electronic Publication: 2024 Apr 20.
DOI: 10.1016/j.ygcen.2024.114528
Abstrakt: Kisspeptin is a peptide that plays an important role through its effects on the hypothalamus-pituitary-gonadal (HPG) axis. It has also been implicated in sexual behavior. The present study investigated whether the relationship between kisspeptin and sexual behavior is independent of the HPG axis, i.e., testosterone. Sexual behavior was examined after the administration of kisspeptin to gonadally intact male rats and gonadectomized male rats that received testosterone supplementation. Other male rats were also observed for sexual behavior once a week from 2 to 5 weeks after gonadectomy and receiving kisspeptin for the sixth postoperative week. Sexual behavior in female rats serving as the partner for each male was also observed. Female rats were not administered kisspeptin in the present study. The results obtained showed that the administration of kisspeptin increased precopulatory behavior in gonadally intact male rats and gonadectomized male rats that received testosterone supplementation and proceptive behavior in their female partners. Precopulatory behavior in males and receptive behavior in females increased, while copulatory behavior in males and receptive behavior in females remained unchanged. Furthermore, the administration of kisspeptin increased precopulatory behavior in gonadectomized males, but did not affect receptive behavior in females. These results suggest that kisspeptin affected males independently and/or supplementally to testosterone, and also that changes in the presence of testosterone in males had an impact on proceptive behavior in their female partners. In conclusion, kisspeptin may involve an as-yet-unidentified neural pathway in sexual desire independently of the HPG axis.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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