Mild exercise expedites joint clearance and slows joint degradation in a joint instability model of osteoarthritis in male rats.

Autor: Kaiser JM; Atlanta Veterans Affairs Hospital, Decatur, GA, USA; Emory University School of Medicine, Decatur, GA, USA. Electronic address: jarred.kaiser@emory.edu., Bernard FC; Emory University School of Medicine, Decatur, GA, USA; Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: fbernard6@gatech.edu., Pucha K; Emory University School of Medicine, Decatur, GA, USA. Electronic address: ananthupucha@gmail.com., Raval SK; Emory University School of Medicine, Decatur, GA, USA. Electronic address: sarvgna@gmail.com., Eng T; Atlanta Veterans Affairs Hospital, Decatur, GA, USA; Emory University School of Medicine, Decatur, GA, USA. Electronic address: tracy.eng@emory.edu., Fulton T; Atlanta Veterans Affairs Hospital, Decatur, GA, USA; Emory University School of Medicine, Decatur, GA, USA. Electronic address: tmfulto@emory.edu., Anderson SE; Emory University School of Medicine, Decatur, GA, USA; Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: sanderson270@gmail.com., Allen KD; University of Florida, Gainesville, FL, USA. Electronic address: kyle.allen@bme.ufl.edu., Dixon JB; Emory University School of Medicine, Decatur, GA, USA; Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: dixon@gatech.edu., Willett NJ; Atlanta Veterans Affairs Hospital, Decatur, GA, USA; Emory University School of Medicine, Decatur, GA, USA; Georgia Institute of Technology, Atlanta, GA, USA; Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA. Electronic address: nwillett@uoregon.edu.
Jazyk: angličtina
Zdroj: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2024 Jul; Vol. 32 (7), pp. 912-921. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1016/j.joca.2024.03.120
Abstrakt: Objective: Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow the progression of preclinical PTOA in part by enhancing knee joint clearance.
Design: Surgical medial meniscal transection was used to induce PTOA in 3-month-old male Lewis rats. A sham surgery was used as a control. Mild treadmill walking was introduced 3 weeks post-surgery and maintained to 6 weeks post-surgery. Gait and isometric muscle torque were measured at the study endpoint. Near-infrared imaging tracked how exercise altered lymphatic and venous knee joint clearance during discrete time points of PTOA progression.
Results: Exercise mitigated joint degradation associated with PTOA by preserving glycosaminoglycan content and reducing osteophyte volume (effect size (95% Confidence Interval (CI)); 1.74 (0.71-2.26)). PTOA increased hind step widths (0.57 (0.18-0.95) cm), but exercise corrected this gait dysfunction (0.54 (0.16-0.93) cm), potentially indicating pain relief. Venous, but not lymphatic, clearance was quicker 1-, 3-, and 6-weeks post-surgery compared to baseline. The mild treadmill walking protocol expedited lymphatic clearance rate in moderate PTOA (3.39 (0.20-6.59) hrs), suggesting exercise may play a critical role in restoring joint homeostasis.
Conclusions: We conclude that mild exercise has the potential to slow disease progression in part by expediting joint clearance in moderate PTOA.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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