Characterization and quantification of epilepsy patients with hospital episodes in Portugal: A multicenter retrospective study from Liga Portuguesa Contra a Epilepsia.

Autor: Bentes C; Reference Centre for Refractory Epilepsies (member of EpiCARE), Centro Hospitalar Universitário Lisboa Norte-Hospital de Santa Maria, Lisboa, Portugal; Department of Neurosciences and Mental Health (Neurology), Centro Hospitalar Universitário Lisboa Norte - Hospital de Santa Maria, Lisboa, Portugal; Egas Moniz Centre of Studies. Medical Faculty, Universidade de Lisboa, Lisboa, Portugal; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal. Electronic address: ccbentes@gmail.com., Canas N; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neurology Department, Hospital Beatriz Ângelo, Lisboa, Portugal; Reference Centre for Refractory Epilepsies, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal., Pedrosa H; IQVIA Solutions Portugal, RWAS, Oeiras, Portugal., Completo J; IQVIA Solutions Portugal, IASIST - Payers, Providers and Government, Oeiras, Portugal., Pereira F; IQVIA Solutions Portugal, RWAS, Oeiras, Portugal., Carrilho M; IQVIA Solutions Portugal, RWAS, Oeiras, Portugal., Lopes Lima J; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neurology Department, Hospital Lusíadas Porto, Porto, Portugal; Neurology Department, Hospital da Misericórdia do Porto, Porto, Portugal; Neurology Department, Hospital da Luz Arrábida, Vila Nova de Gaia, Portugal., Pereira C; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neuropediatrics and Neurophysiology Department - Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Reference Centre for Refractory Epilepsies (member of EpiCARE), Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Rego R; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neurophysiology Unit, Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; Reference Centre for Refractory Epilepsies, Centro Hospitalar e Universitário de São João, Porto, Portugal., Rocha H; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neurophysiology Unit, Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; Reference Centre for Refractory Epilepsies, Centro Hospitalar e Universitário de São João, Porto, Portugal., Sá F; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Reference Centre for Refractory Epilepsies, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal; Neurology Department, Hospital Egas Moniz, Lisboa, Portugal., Sales F; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Reference Centre for Refractory Epilepsies (member of EpiCARE), Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Neurophysiology Unit, Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal., Santos M; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Neuropediatrics Department, Centro Hospitalar e Universitário de Santo António, Porto, Portugal; Reference Centre for Refractory Epilepsies (member of EpiCARE), Centro Hospitalar e Universitário de Santo António, Porto, Portugal., Teotónio R; Liga Portuguesa Contra a Epilepsia (Portuguese Chapter of the International League Against Epilepsy), Portugal; Reference Centre for Refractory Epilepsies (member of EpiCARE), Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Neurophysiology Unit, Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Jun; Vol. 155, pp. 109771. Date of Electronic Publication: 2024 Apr 19.
DOI: 10.1016/j.yebeh.2024.109771
Abstrakt: Introduction: Epilepsy affects around 50 million people worldwide and is associated with lower quality of life scores, an increased risk of premature death, and significant socio-economic implications. The lack of updated evidence on current epidemiology and patient characterization creates considerable uncertainty regarding the epilepsy burden in Portugal. The study aims to characterize and quantify the epilepsy patients who have been hospitalized, with medical or surgical procedures involved, and to analyze their associated comorbidities and mortality rates.
Methods: A multicenter retrospective study was conducted using hospital production data of epilepsy patients. The study included all patients diagnosed with epilepsy-related International Classification of Diseases-9/10 codes between 2015 and 2018 in 57 Portuguese National Health Service (NHS) hospitals (n = 57 institutions). Patient characterization and quantification were done for all patients with an epilepsy diagnosis, with specific analyses focusing on those whose primary diagnosis was epilepsy. Baseline, demographic, and clinical characteristics were analyzed using descriptive statistics.
Results: Between 2015 and 2018, a total of 80,494 hospital episodes (i.e., patient visit that generates hospitalization and procedures) were recorded, with 18 % to 19 % directly related to epilepsy. Among these epilepsy-related hospital episodes, 13.0 % led to short term hospitalizations (less than 24 h). Additionally, the average length of stay for all these epilepsy-related episodes was 8 days. A total of 49,481 patients were identified with epilepsy based on ICD-9/10 codes. The median age of patients was 64 years (min: 0; max: 104), with a distribution of 4.8 patients per 1,000 inhabitants. From the total of deaths (9,606) between 2015 and 2018, 14% were associated with patients whose primary diagnosis was epilepsy, with 545 of these being epilepsy-related deaths. Among patients with a primary diagnosis of epilepsy, the most common comorbidities were hypertension (24%) and psychiatric-related or similar comorbidities (15%), such as alcohol dependance, depressive and major depressive disorders, dementia and other convulsions.
Conclusion: This study showed similar results to other European countries. However, due to methodological limitations, a prospective epidemiological study is needed to support this observation. Furthermore, the present study provides a comprehensive picture of hospitalized epilepsy patients in Portugal, their comorbidities, mortality, and hospital procedures.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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