Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse case report and literature review of cholangiocarcinoma in horses.

Autor:	Barrantes Murillo DF; Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., Cattley RC; Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., Cullen JM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.; Current addresses: Gastrointestinal Laboratory, School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA., Withers C; Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., Towns J; Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., Pfeifle R; Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA., Wooldridge A; Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA., Neto RLALT; Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
Jazyk:	angličtina
Zdroj:	Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2024 Jul; Vol. 36 (4), pp. 547-553. Date of Electronic Publication: 2024 Apr 20.
DOI:	10.1177/10406387241245775
Abstrakt:	A 17-y-old Arabian mare was presented to the Auburn Large Animal Veterinary Teaching Hospital with a long-term history of intermittent mild recurrent colic that responded to medical treatment. CBC revealed mild lymphopenia; serum biochemistry findings were of increased gamma-glutamyl transferase and creatine kinase activities, hyperferremia, hyperglycemia, hypomagnesemia, and hypokalemia. Abdominocentesis was compatible with low-protein transudate. Due to the progression and duration of clinical signs, the owner elected euthanasia. Postmortem examination and histopathology confirmed a cholangiocarcinoma. The neoplastic cells were arranged in large cysts containing lakes of mucin that comprised 90% of the tumor volume; thus, a mucinous variant was determined. The neoplastic cells had strong cytoplasmic immunolabeling for cytokeratin 19 and lacked immunolabeling for hepatocyte paraffin 1, supporting bile duct origin. Cholangiocarcinomas are infrequent tumors in horses with nonspecific and slow progressive clinical signs, including recurrent colic. Mucinous cholangiocarcinomas are seldom reported in veterinary medicine and, to our knowledge, have not been reported previously in horses. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest concerning the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu