Multiparametric MRI for characterization of the tumour microenvironment.

Autor: Hoffmann E; Clinic of Radiology, University of Münster, Münster, Germany., Masthoff M; Clinic of Radiology, University of Münster, Münster, Germany., Kunz WG; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Seidensticker M; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Bobe S; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany., Gerwing M; Clinic of Radiology, University of Münster, Münster, Germany., Berdel WE; Department of Medicine A, University of Münster, Münster, Germany., Schliemann C; Department of Medicine A, University of Münster, Münster, Germany., Faber C; Clinic of Radiology, University of Münster, Münster, Germany., Wildgruber M; Department of Radiology, University Hospital, LMU Munich, Munich, Germany. Moritz.Wildgruber@med.uni-muenchen.de.
Jazyk: angličtina
Zdroj: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2024 Jun; Vol. 21 (6), pp. 428-448. Date of Electronic Publication: 2024 Apr 19.
DOI: 10.1038/s41571-024-00891-1
Abstrakt: Our understanding of tumour biology has evolved over the past decades and cancer is now viewed as a complex ecosystem with interactions between various cellular and non-cellular components within the tumour microenvironment (TME) at multiple scales. However, morphological imaging remains the mainstay of tumour staging and assessment of response to therapy, and the characterization of the TME with non-invasive imaging has not yet entered routine clinical practice. By combining multiple MRI sequences, each providing different but complementary information about the TME, multiparametric MRI (mpMRI) enables non-invasive assessment of molecular and cellular features within the TME, including their spatial and temporal heterogeneity. With an increasing number of advanced MRI techniques bridging the gap between preclinical and clinical applications, mpMRI could ultimately guide the selection of treatment approaches, precisely tailored to each individual patient, tumour and therapeutic modality. In this Review, we describe the evolving role of mpMRI in the non-invasive characterization of the TME, outline its applications for cancer detection, staging and assessment of response to therapy, and discuss considerations and challenges for its use in future medical applications, including personalized integrated diagnostics.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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