Age-specific prevalence of IgG against measles/rubella and the impact of routine and supplementary immunization activities: A multistage random cluster sampling study with mathematical modelling.

Autor:	Hachiya M; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address: m-hachiya@it.ncgm.go.jp., Vynnycky E; United Kingdom Health Security Agency, London, UK; London School of Hygiene & Tropical Medicine, London, UK., Mori Y; Department of Virology 3 and World Health Organization Global Specialized Laboratory for Measles and Rubella, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan., Do HT; Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Huynh MK; Microbiology and Immunology, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Trinh LH; Microbiology and Immunology, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Nguyen DD; Microbiology and Immunology, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Tran NAT; Microbiology and Immunology, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Hoang TT; Infectious Diseases Control and Prevention, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Hoang HHT; Infectious Diseases Control and Prevention, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Vo NDT; Infectious Diseases Control and Prevention, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Le TH; Infectious Diseases Control and Prevention, Pasteur Institute in Nha Trang, Nha Trang City, Viet Nam., Ichimura Y; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Miyano S; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Okawa S; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Thandar MM; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Yokobori Y; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Inoue Y; Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Mizoue T; Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Takeda M; Department of Virology 3 and World Health Organization Global Specialized Laboratory for Measles and Rubella, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan., Komada K; Bureau of International Health Cooperation and World Health Organization Collaborating Center for Health Systems Development, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jul; Vol. 144, pp. 107053. Date of Electronic Publication: 2024 Apr 17.
DOI:	10.1016/j.ijid.2024.107053
Abstrakt:	Background: Vietnam continues to have measles and rubella outbreaks following supplementary immunization activities (SIA) and routine immunization despite both having high reported coverage. To evaluate immunization activities, age-specific immunity against measles and rubella, and the number of averted Congenital Rubella Syndrome (CRS) cases, must be estimated. Methods: Dried blood spots were collected from 2091 randomly selected individuals aged 1-39 years. Measles and rubella virus-specific immunoglobulin G (IgG) were measured by enzyme immunoassay. Results were considered positive at ≥120 mIU/mL for measles and ≥10 IU/mL for rubella. The number of CRS cases averted by immunization since 2014 were estimated using mathematical modelling. Results: Overall IgG seroprevalence was 99.7% (95%CI: 99.2-99.9) for measles and 83.6% (95%CI: 79.3-87.1) for rubella. Rubella IgG seroprevalence was higher among age groups targeted in the SIA than in non-targeted young adults (95.4% [95%CI: 92.9-97.0] vs 72.4% [95%CI: 63.1-80.1]; P < 0.001). The estimated number of CRS cases averted in 2019 by immunization activities since 2014 ranged from 126 (95%CI: 0-460) to 883 (95%CI: 0-2271) depending on the assumed postvaccination reduction in the force of infection. Conclusions: The results suggest the SIA was effective, while young adults born before 1998 who remain unprotected for rubella require further vaccination. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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