The association between alterations in motor and cognitive dimensions of schizophrenia-spectrum disorders: A systematic review.

Autor: Moura BM; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal; Universidade Católica Portuguesa, Faculdade de Medicina, Estrada Octávio Pato, 2635-631 Rio de Mouro, Portugal. Electronic address: bernardo.m.moura@gmail.com., Madeira L; Universidade Católica Portuguesa, Faculdade de Medicina, Estrada Octávio Pato, 2635-631 Rio de Mouro, Portugal; Área Disciplinar Ética e Deontologia Médica, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal., Bakker PR; Department of Research, Arkin Mental Health Care, Klaprozenweg 111, 1033 NN Amsterdam, the Netherlands; Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, 9713 GZ Groningen, the Netherlands. Electronic address: proberto@soverin.net., van Harten P; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands; Center for Expertise on Side Effects, GGz Centraal, Boomgaardweg 12, 1326 AD Almere, the Netherlands., Marcelis M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands; GGzE Institute for Mental Health Care Eindhoven, Dr. Poletlaan 39, 5626 ND Eindhoven, the Netherlands. Electronic address: m.marcelis@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 May; Vol. 267, pp. 398-414. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1016/j.schres.2024.04.014
Abstrakt: Motor and cognitive alterations in schizophrenia-spectrum disorders (SSD) share common neural underpinnings, highlighting the necessity for a thorough exploration of the connections between these areas. This relationship is crucial, as it holds potential significance in unraveling the underlying mechanisms of SSD pathophysiology, ultimately leading to advancements in clinical staging and treatment strategies. The purpose of this review was to characterize the relationship between different hyper and hypokinetic domains of motor alterations and cognition in SSD. We systematically searched the literature (PROSPERO protocol CRD42019145964) and selected 66 original scientific contributions for review, published between 1987 and 2022. A narrative synthesis of the results was conducted. Hyper and hypokinetic motor alterations showed weak to moderate negative correlations with cognitive function across different SSD stages, including before antipsychotic treatment. The literature to date shows a diverse set of methodologies and composite cognitive scores hampering a strong conclusion about which specific cognitive domains were more linked to each group of motor alterations. However, executive functions seemed the domain more consistently associated with parkinsonism with the results regarding dyskinesia being less clear. Akathisia and catatonia were scarcely discussed in the reviewed literature. The present review reinforces the intimate relationship between specific motor alterations and cognition. Identified gaps in the literature challenge the formulation of definitive conclusions. Nevertheless, a discussion of putative underlying mechanisms is included, prompting guidance for future research endeavors.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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