Identification of novel dimers and chemical profiling of acid amide alkaloids in Piper nigrum.

Autor: Jung Y; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Choi SY; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Choi JW; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Cho CY; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Lee DK; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Park J; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea., Yang H; College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: heejyang@kangwon.ac.kr., Shim SH; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: sanghee_shim@snu.ac.kr.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Aug 30; Vol. 450, pp. 139199. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1016/j.foodchem.2024.139199
Abstrakt: Peppers (Piper nigrum L.) are distinguished by their pungent flavor and aroma. Piperine is a major acid-amide alkaloid with a piperidine ring that gives pepper its flavor and scent. In plant metabolomics research, the accessibility of the chemical standards is critical for scientific credibility. We isolated and identified 10 novel dimers of acid amide alkaloids (9-15 and 20-22), along with 12 known monomers (1-6) and dimers (7, 8, 16-19) from black pepper. Subsequently, we found the distribution of monomers and dimers of acid amide alkaloids in black and white peppers by twenty-two acid amide alkaloids which we obtained using the molecular networking technique and multivariate analysis to reveal the molecular relationships between the acid amide alkaloids in black and white peppers. Our research delved into the chemical diversity of acid amide alkaloids in black and white peppers, which could help inform future culinary and potential medicinal utilization of pepper.
Competing Interests: Declaration of competing interest Heejung Yang, Sang Hee Shim reports financial support was provided by Cooperative Research Program for Agriculture Science and Technology Development, Rural Development Administration, Republic of Korea. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: