Trends in Incidence of Hospitalization for Hypoglycemia and Diabetic Ketoacidosis in Individuals With Type 1 or Type 2 Diabetes With and Without Severe Mental Illness in Denmark From 1996 to 2020: A Nationwide Study.

Autor:	Scheuer SH; Steno Diabetes Center Copenhagen, Herlev, Denmark., Andersen GS; Steno Diabetes Center Copenhagen, Herlev, Denmark., Carstensen B; Steno Diabetes Center Copenhagen, Herlev, Denmark., Diaz L; Steno Diabetes Center Copenhagen, Herlev, Denmark., Kosjerina V; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Endocrinology, Copenhagen University Hospital, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark., Lindekilde N; Department of Occupational & Environmental Medicine, Odense University Hospital, Odense, Denmark., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, U.K., Jackson CA; Usher Institute, University of Edinburgh, Edinburgh, U.K., Pouwer F; Department of Psychology, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.; Department of Medical Psychology, Amsterdam UMC, Amsterdam, the Netherlands., Benros ME; Copenhagen Research Centre for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen ME; Steno Diabetes Center Greenland, Nuuk, Greenland.; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2024 Jun 01; Vol. 47 (6), pp. 1065-1073.
DOI:	10.2337/dc23-2394
Abstrakt:	Objective: To examine trends in incidence of acute diabetes complications in individuals with type 1 or type 2 diabetes with and without severe mental illness (SMI) in Denmark by age and calendar year. Research Design and Methods: We conducted a cohort study using nationwide registers from 1996 to 2020 to identify individuals with diabetes, ascertain SMI status (namely, schizophrenia, bipolar disorder, or major depression) and identify the outcomes: hospitalization for hypoglycemia and diabetic ketoacidosis (DKA). We used Poisson regression to estimate incidence rates (IRs) and incidence rate ratios (IRRs) of recurrent hypoglycemia and DKA events by SMI, age, and calendar year, accounting for sex, diabetes duration, education, and country of origin. Results: Among 433,609 individuals with diabetes, 8% had SMI. Risk of (first and subsequent) hypoglycemia events was higher for individuals with SMI than for those without SMI (for first hypoglycemia event, IRR: type 1 diabetes, 1.77 [95% CI 1.56-2.00]; type 2 diabetes, 1.64 [95% CI 1.55-1.74]). Individuals with schizophrenia were particularly at risk for recurrent hypoglycemia events. The risk of first DKA event was higher in individuals with SMI (for first DKA event, IRR: type 1 diabetes, 1.78 [95% CI 1.50-2.11]; type 2 diabetes, 1.85 [95% CI 1.64-2.09]). Except for DKA in the type 2 diabetes group, IR differences between individuals with and without SMI were highest in younger individuals (<50 years old) but stable across the calendar year. Conclusions: SMI is an important risk factor for acute diabetes complication and effective prevention is needed in this population, especially among the younger population and those with schizophrenia. (© 2024 by the American Diabetes Association.)
Databáze:	MEDLINE
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