Copper Deficiency Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus.

Autor: Menezes-Santos M; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Santos BDC; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil., Santos RKF; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.; Health Sciences Post-Graduation Program, Department of Medicine, Center for Biological and Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., da Costa SSL; Nucleus of Competence in Oil, Gas and Biofuels - NUPEG, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Dos Santos SH; Chemistry Post-Graduation Program, Chemistry Institute, Federal University of Bahia, Salvador, Bahia, Brazil., E Silva AMO; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil.; Health Sciences Post-Graduation Program, Department of Medicine, Center for Biological and Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Rocha VS; Department of Nutrition, Federal University of Sergipe, Lagarto, Sergipe, Brazil., Pires LV; Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. lvianapires@gmail.com.; Nutrition Sciences Post-Graduation Program, Department of Nutrition, Center for Biological and Health Sciences, Federal University of Sergipe, Marcelo Deda Avenue, S/n - Jardim Rosa Elze, São Cristóvão, Sergipe, ZIP: 49107-230, Brazil. lvianapires@gmail.com.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Apr 19. Date of Electronic Publication: 2024 Apr 19.
DOI: 10.1007/s12011-024-04185-6
Abstrakt: Adequate copper (Cu) status has been associated with improved glycemic control, partly because of its role in reducing oxidative stress through superoxide dismutase (SOD) activity. Thus, the aim was to investigate the relationship between plasma Cu concentration and markers associated with glycemic control in individuals with type 2 diabetes mellitus (T2DM). This observational and cross-sectional study was conducted in individuals with T2DM of both sexes, aged between 19 and 59 years. Plasma Cu levels were analyzed using inductively coupled plasma optical emission spectrometry (ICP-OES). Fasting glucose and insulin concentrations, C-peptide levels, SOD activity, and glycated hemoglobin (%HbA1c) were measured. Homeostatic model assessments (HOMA%B, HOMA%S, and HOMA-IR) were also performed. Additionally, %body fat and waist circumference were measured, and body mass index was calculated. Participants were categorized based on their plasma Cu concentrations (< 70 µg/dL and ≥ 70 µg/dL). The associations between variables were analyzed using chi-squared or Fisher's test and binary logistic regression models. Statistical significance was set at P < 0.05. Of the 97 participants (74.2% women), 85.5% had Cu deficiency. Cu-deficient individuals showed elevated C-peptide concentrations and HOMA%B values compared to those with adequate Cu levels (2.8 ng/mL vs. 1.8 ng/mL, P = 0.011; and 71.4 vs. 31.0, P = 0.003), respectively. Cu deficiency was associated with insulin resistance (P = 0.044) and decreased likelihood of exceeding the target serum glucose level (OR = 0.147, P = 0.013). However, no significant association was found between SOD activity and plasma Cu concentration. Consequently, Cu deficiency was linked to improved glycemic control, although it was not associated with the other markers.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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