Efficacy of natural enzymes mouthwash: a randomised controlled trial.

Autor: Chiam TL; Faculty of Dentistry, The National University of Malaysia (UKM), Kuala Lumpur, Malaysia., Choo J; Ayer Molek Dental Clinic, Ministry of Health, Malacca, Malaysia., Ashar A; Faculty of Dentistry, The National University of Malaysia (UKM), Kuala Lumpur, Malaysia., Hussaini HM; Faculty of Dentistry, University of Otago, Dudenin, New Zealand.; Faculty of Dental Medicine, Kampus A Universitas Airlangga, Surabaya, Indonesia., Rajandram RK; Faculty of Dentistry, The National University of Malaysia (UKM), Kuala Lumpur, Malaysia., Nordin R; Faculty of Dentistry, The National University of Malaysia (UKM), Kuala Lumpur, Malaysia. rifqahnordin@ukm.edu.my.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Apr 19; Vol. 28 (5), pp. 259. Date of Electronic Publication: 2024 Apr 19.
DOI: 10.1007/s00784-024-05658-7
Abstrakt: Objectives: Natural enzymes mouthwash has been proposed as salivary substitutes to treat xerostomia. This study aims to evaluate the efficacy of the mouthwash to treat xerostomia.
Materials and Methods: A double-blind, parallel group randomised control clinical trial involving N = 49 adult participants with xerostomia was carried out. Intervention group received natural enzymes moisturising mouthwash (with active ingredients lactoferrin, lysozyme, lactoperoxidase and glucose oxidase); while control group received benzydamine mouthwash. Mouthwashes were repacked, labelled with specific code, and were given to participants by third-party. Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks. Symptoms of xerostomia were assessed using Xerostomia Inventory at day 0 and 14; together with the assessment of Clinical Oral Dryness Score (CODS), and measurement of resting and stimulated salivary flow rate.
Results: 48 participants completed the clinical follow-up, and n = 1 had lost of follow-up. From the 48 participants, n = 23 received natural enzymes mouthwash, while n = 25 received benzydamine mouthwash. Intervention group achieved reduction in symptoms of xerostomia from baseline. Intervention group also showed significantly better improvements in the cognitive perception of dry mouth and oromotor function such as chewing, swallowing and speech of the participants; and reduction in waking up at night to drink water (p < 0.05). The CODS and resting salivary flow rate were also significantly improved in intervention group (p < 0.05).
Conclusion: Use of natural enzymes mouthwash improved signs and symptoms of xerostomia.
Clinical Relevance: Natural enzymes mouthwash is potentially effective to treat xerostomia, well-tolerated and safe to be used by xerostomia patients.
Clinical Trial Registration Number: This study was retrospectively registered in ClinicalTrials.gov ID NCT05640362 on 7 December 2022.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: