| Autor: |
Dai YW; Department of Transfusion Medicine， Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China., Zhang XK; Department of Reproductive Medicine， The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China., Li HG; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2023 Sep; Vol. 29 (9), pp. 851-855. |
| Abstrakt: |
Non-obstract azoospermia (NOA) is a serious male infertility disease. At present, testicular sperm extraction (micro-TESE) is performed in combination with intracytoplasmic sperm injection (ICSI) technology, NOA patients can have their own consanguine offspring. However, due to the invasiveness and uncertainty of micro-TESE surgery, it is difficult for patients to accept it. Therefore, finding an accurate method to predict the possibility of micro-TESE successful sperm retrival would be beneficial to azoospermia patients. Many genes are transcribed and expressed during spermatogenesis, and molecular assays have irreplaceable sensitivity and specificity in predicting the success sperm retrivel of micro-TESE. This article reviews the methods to predict the success sperm retrivel of micro-TESE including mRNA, non-coding RNA (piRNA, microRNA, cirRNA, tFRNAs) and some protein so far, to provide certain reference value for clinical and subsequent research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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