The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT.

Autor: Stormlund S; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Sopa N; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Lyng Forman J; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Zedeler A; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Bogstad J; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Prætorius L; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Nielsen HS; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Klajnbard A; The Fertility Clinic, Department of Obstetrics and Gynaecology, Herlev University Hospital, Copenhagen, Denmark., Englund AL; The Fertility Clinic, Department of Obstetrics and Gynaecology, Zealand University Hospital, Køge., Ziebe S; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Freiesleben NC; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; The Fertility Clinic, Skive Regional Hospital and Faculty of Health, Aarhus University, Aarhus, Denmark., Bergh C; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Humaidan P; The Fertility Clinic, Skive Regional Hospital and Faculty of Health, Aarhus University, Aarhus, Denmark., Nyboe Andersen A; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Pinborg A; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Løssl K; The Fertility Clinic, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Human fertility (Cambridge, England) [Hum Fertil (Camb)] 2024 Dec; Vol. 27 (1), pp. 2265153. Date of Electronic Publication: 2024 Apr 19.
DOI: 10.1080/14647273.2023.2265153
Abstrakt: The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on trigger day . Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis ( n  = 312) only age, but not progesterone level on trigger day was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.
Databáze: MEDLINE
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