A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications.

Autor:	Huang H; School of Pharmacy, Macau University of Science and Technology, Taipa, Macao SAR, China.; School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Peng Z; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Zhan S; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Li W; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Liu D; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Huang S; Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha, Hunan, China.; Hunan Natural Sweetener Engineering Technology Research Center, Changsha, Hunan, China., Zhu Y; School of Pharmacy, Macau University of Science and Technology, Taipa, Macao SAR, China., Wang W; School of Pharmacy, Macau University of Science and Technology, Taipa, Macao SAR, China.; School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Apr 04; Vol. 15, pp. 1388747. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1388747
Abstrakt:	Siraitia grosvenorii (Swingle) C. Jeffrey ( S. grosvenorii ), a perennial indigenous liana from the Cucurbitaceae family, has historically played a significant role in southern China's traditional remedies for various ailments. Its dual classification by the Chinese Ministry of Health for both medicinal and food utility underscores its has the potential of versatile applications. Recent research has shed light on the chemical composition, pharmacological effects, and toxicity of S. grosvenorii . Its active ingredients include triterpenoids, flavonoids, amino acids, volatile oils, polysaccharides, minerals, vitamins, and other microconstituents. Apart from being a natural sweetener, S. grosvenorii has been found to have numerous pharmacological effects, including alleviating cough and phlegm, preventing dental caries, exerting anti-inflammatory and anti-allergic effects, anti-aging and anti-oxidative, hypoglycemic, lipid-lowering, anti-depression, anti-fatigue, anti-schizophrenic, anti-Parkinson, anti-fibrotic, and anti-tumor activities. Despite its versatile potential, there is still a lack of systematic research on S. grosvenorii to date. This paper aims to address this gap by providing an overview of the main active components, pharmacological efficacy, toxicity, current status of development and application, development dilemmas, and strategies for intensive exploitation and utilization of S. grosvenorii . This paper aims to serve as a guide for researchers and practitioners committed to exploiting the biological resources of S. grosvenorii and further exploring its interdisciplinary potential. Competing Interests: Authors HH, ZP, SZ, WL, DL, SH were employed by Hunan Huacheng Biotech, Inc. Authors HH, ZP, SZ, WL, DL, SH were employed by Hunan Natural Sweetener Engineering Technology Research Center. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Huang, Peng, Zhan, Li, Liu, Huang, Zhu and Wang.)
Databáze:	MEDLINE
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