Effect of docosahexaenoic acid and olive oil supplementation on pup weight in alcohol-exposed pregnant rats.

Autor:	Yadav D; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States., Ostrea EM Jr; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States., Cheng CT; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States., Kisseih E; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States., Maddipati KR; Bioactive Lipids Research Program, Wayne State University School of Medicine, Detroit, MI, United States., Thomas RL; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2024 Apr 04; Vol. 12, pp. 1334285. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
DOI:	10.3389/fped.2024.1334285
Abstrakt:	Background: Low birth weight has been observed in offspring of alcoholic mothers due likely to unresolved inflammation and oxidative injury. Dietary lipids play a role in inflammation and its resolution. The primary objective was to investigate the effect of DHA and olive oil on the birth weight of pups born to alcohol-exposed dams. Methods: Pregnant rats were randomized to the control or three treatment (alcohol) groups. From gestational days (GD) 8-19, the control group received daily olive oil and malto/dextrose, whereas groups 2 and 3 received olive oil and low-dose alcohol or high-dose alcohol, respectively. Group 4 received daily DHA and high-dose alcohol. The dam's blood was collected on GD 15 and 20 for cytokine analysis. Dams were sacrificed on GD 20. The mean birth weight of pups was compared by one-way ANOVA with post hoc Duncan's test. Results: There was a significant increase in the pups' mean birth weight in the high-dose alcohol/DHA and high-dose alcohol/olive oil. Higher pro-inflammatory cytokines (IL-1β and IL-12p70) were noted in the alcohol-exposed dams. Conclusions: DHA and olive oil supplementation in alcohol-exposed pregnant rats significantly increased their pups' birth weight despite having high pro-inflammatory cytokines. The mechanism of this effect remains to be determined. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Yadav, Ostrea, Cheng, Kisseih, Maddipati and Thomas.)
Databáze:	MEDLINE
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