Rational Design and Synthesis of Isatin-Chalcone Hybrids Integrated with 1H-1,2,3-Triazole: Anti-Proliferative Profiling and Molecular Docking Insights.

Autor: Swati; Department of Chemistry, Maharaja Ranjit Singh Punjab Technical University, Dabwali Road, Bathinda, India., Raza A; Department of Pharmacology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA., Chowdhary S; Department of Chemistry, Guru Nanak Dev University, Amritsar, India., Anand A; Department of Chemistry, Khalsa College, Amritsar, India., Shaveta; Department of Chemistry, Baba Farid College, Muktsar Road, Bathinda, India., Sharma AK; Department of Pharmacology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA., Kumar K; Department of Chemistry, Maharaja Ranjit Singh Punjab Technical University, Dabwali Road, Bathinda, India., Kumar V; Department of Chemistry, Guru Nanak Dev University, Amritsar, India.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Jul 15; Vol. 19 (14), pp. e202400015. Date of Electronic Publication: 2024 May 22.
DOI: 10.1002/cmdc.202400015
Abstrakt: In this study, a series of isatin-chalcone linked triazoles were synthesized using Cu-promoted Azide-Alkyne Cycloaddition (CuAAC) reaction and evaluated for their cytotoxicity against various cancer cell lines. The most potent compound displayed approximately 2.5 times greater activity compared to both reference compounds against ovarian cancer cell lines. These findings were supported by caspase-mediated apoptosis and molecular docking analyses. Docking revealed comparable VEGFR-2 affinities for 5 b and 5-FU but highlighted stronger interaction of 5 b with EGFR, evident from its lower docking score. Overall, these results signify the notable anti-proliferative potential of most synthesized hybrids, notably emphasizing the efficacy of compound 5 b in suppressing cancer cell growth.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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