Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults ≥ 50 years: a prospective, observational cohort study.

Autor: Gaultier GN; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada. gabrielle.gaultier@bcchr.ca.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada. gabrielle.gaultier@bcchr.ca., McMillan B; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Experimental Medicine Program, University of British Columbia, Vancouver, BC, Canada., Poloni C; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Lo M; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada., Cai B; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada., Zheng JJ; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Baer HM; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Institute of Infection, Inflammation & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Shulha HP; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada., Simmons K; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada., Márquez AC; British Columbia Centre for Disease Control, Vancouver, BC, Canada., Bartlett SR; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Cook L; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Levings MK; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Surgery, University of British Columbia, Vancouver, BC, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Steiner T; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Sekirov I; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Zlosnik JEA; British Columbia Centre for Disease Control, Vancouver, BC, Canada., Morshed M; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Skowronski DM; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Krajden M; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Jassem AN; British Columbia Centre for Disease Control, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Sadarangani M; Department of Pediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Vaccine Evaluation Center, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Apr 18; Vol. 14 (1), pp. 8926. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1038/s41598-024-59535-0
Abstrakt: To evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and function (via angiotensin-converting enzyme 2 (ACE2) inhibition surrogate neutralization and antibody dependent cellular phagocytosis (ADCP)), as well as S-specific T cells were quantified via activation induced marker (AIM) assay in response to two-dose series. Eighty-four adults were vaccinated with either: mRNA/mRNA (mRNA-1273 and/or BNT162b2); ChAdOx1-S/mRNA; or ChAdOx1-S/ChAdOx1-S. Anti-S IgG concentrations, ADCP scores and ACE2 inhibiting antibody concentrations were highest at one-month post-second dose and declined by four-months post-second dose for all groups. mRNA/mRNA and ChAdOx1-S/mRNA schedules had significantly higher antibody responses than ChAdOx1-S/ChAdOx1-S. CD8 + T-cell responses one-month post-second dose were associated with increased ACE2 surrogate neutralization. Antibody avidity (total relative avidity index) did not change between one-month and four-months post-second dose and did not significantly differ between groups by four-months post-second dose. In determining COVID-19 correlates of protection, a measure that considers both antibody concentration and avidity should be considered.
(© 2024. The Author(s).)
Databáze: MEDLINE
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