Apicomplexa micropore: history, function, and formation.

Autor: Yang J; MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, P. R. China., Long S; National Animal Protozoa Laboratory and School of Veterinary Medicine, China Agricultural University, Beijing 100193, P. R. China., Hide G; Biomedical Research and Innovation Centre, School of Science, Engineering, and Environment, University of Salford, Salford M5 4WT, UK., Lun ZR; MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, P. R. China., Lai DH; MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, P. R. China. Electronic address: laidehua@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2024 May; Vol. 40 (5), pp. 416-426. Date of Electronic Publication: 2024 Apr 17.
DOI: 10.1016/j.pt.2024.03.008
Abstrakt: The micropore, a mysterious structure found in apicomplexan species, was recently shown to be essential for nutrient acquisition in Plasmodium falciparum and Toxoplasma gondii. However, the differences between the micropores of these two parasites questions the nature of a general apicomplexan micropore structure and whether the formation process model from Plasmodium can be applied to other apicomplexans. We analyzed the literature on different apicomplexan micropores and found that T. gondii probably harbors a more representative micropore type than the more widely studied ones in Plasmodium. Using recent knowledge of the Kelch 13 (K13) protein interactome and gene depletion phenotypes in the T. gondii micropore, we propose a model of micropore formation, thus enriching our wider understanding of micropore protein function.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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