Increased anxiolytic effect in aged female rats and increased motoric behavior in aged male rats to acute alcohol administration: Comparison to younger animals.

Autor: Matthews DB; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America. Electronic address: matthedb@uwec.edu., Rossmann G; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America., Matthews SJ; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America., Zank A; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America., Shult C; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America., Turunen A; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI 54701, United States of America., Sharma P; Department of Psychiatry and Psychology, Mayo Clinic Health System, Eau Claire, WI 54703, United States of America.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2024 Jun; Vol. 239, pp. 173770. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.1016/j.pbb.2024.173770
Abstrakt: The population of most countries in the world is increasing and understanding risk factors that can influence the health of the older population is critical. Older adults consume alcohol often in a risky, binge manner. Previous work has demonstrated that aged rats are more sensitive to many of the effects of acute ethanol. In the current project aged, adult, and adolescent female and male rats were tested on the elevated plus maze and open field following either a 1.0 g/kg alcohol injection or a saline injection. We report sex- and age-dependent effects whereas aged female rats, but not aged male rats, showed an increased anxiolytic effect of alcohol in the elevated plus maze while aged male rats, but not aged female rats, showed increased stimulatory movement in the open field. In addition, significant age effects were found for both female and male rats. It is proposed that the sex- and age-dependent effects reported in the current studies may be due to differential levels of alcohol-induced allopregnanolone for the anxiolytic effects and differential levels of alcohol-induced dopamine for the stimulatory effects. The current work provides insights into factors influencing alcohol consumption in older adults.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: