Protecting Proteins from Desiccation Stress Using Molecular Glasses and Gels.

Autor:	Olgenblum GI; Institute of Chemistry, Fritz Haber Research Center, and The Harvey M. Krueger Family Center for Nanoscience & Nanotechnology, The Hebrew University, Jerusalem 9190401, Israel., Hutcheson BO; Department of Chemistry, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, North Carolina 27599, United States., Pielak GJ; Department of Chemistry, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, North Carolina 27599, United States.; Department of Chemistry, Department of Biochemistry & Biophysics, Integrated Program for Biological & Genome Sciences, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Harries D; Institute of Chemistry, Fritz Haber Research Center, and The Harvey M. Krueger Family Center for Nanoscience & Nanotechnology, The Hebrew University, Jerusalem 9190401, Israel.
Jazyk:	angličtina
Zdroj:	Chemical reviews [Chem Rev] 2024 May 08; Vol. 124 (9), pp. 5668-5694. Date of Electronic Publication: 2024 Apr 18.
DOI:	10.1021/acs.chemrev.3c00752
Abstrakt:	Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of their cellular components. Amorphous glassy media composed of small molecular solutes or protein gels present general strategies for protecting against drying. We review these strategies and the proposed molecular mechanisms to explain protein protection in a vitreous matrix under conditions of low hydration. We also describe efforts to exploit similar strategies in technological applications for protecting proteins in dry or highly desiccated states. Finally, we outline open questions and possibilities for future explorations.
Databáze:	MEDLINE
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