Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.

Autor: Karagianni A; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.; Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece., Karkempetzaki AI; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.; Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece., Brooks D; Center for Musculoskeletal Research, Endocrine Unit, Massachusetts General Hospital, Boston, MA.; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA., Matsuura S; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA., Dambal V; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA., Trackman PC; Department of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA.; Forsyth Institute, Boston, MA., Ravid K; Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Jazyk: angličtina
Zdroj: Blood [Blood] 2024 Jun 20; Vol. 143 (25), pp. 2666-2670.
DOI: 10.1182/blood.2024024620
Abstrakt: Abstract: Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.
(© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
Databáze: MEDLINE
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