Bacterial and fungal secondary infections occurring in COVID-19 patients followed in intensive care: a retrospective study.

Autor: Ozyurt E; Department of Anesthesiology and Reanimation, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey., Erman Daloglu A; Department of Medical Microbiology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey., Inanoglu K; Department of Anesthesiology and Reanimation, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey., Kavrut Ozturk N; Department of Anesthesiology and Reanimation, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey., Ozmen S; Department of Anesthesiology and Reanimation, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey.
Jazyk: angličtina
Zdroj: Journal of infection in developing countries [J Infect Dev Ctries] 2024 Mar 31; Vol. 18 (3), pp. 350-354. Date of Electronic Publication: 2024 Mar 31.
DOI: 10.3855/jidc.18480
Abstrakt: Introduction: We aimed to investigate the effects of secondary bacterial and fungal infections on patient outcomes in patients followed up in the intensive care unit (ICU) due to coronavirus disease 2019 (COVID-19).
Methodology: We retrospectively analyzed reverse transcriptase polymerase chain reaction (RT-PCR) positive COVID-19 patients followed in the ICU of our hospital between March 2020 and June 2021, using the hospital information system. Demographic data, pathogens causing a secondary infection, onset time of secondary infection, and patient outcomes were recorded.
Results: A total of 251 RT-PCR positive patients who met the inclusion criteria were evaluated. The mean length of stay (LOS) in the ICU was 13.3 ± 9.6 days. During this period, 165 (65.7%) patients died. When blood, urine, respiratory tract, and catheter cultures were examined, the number of patients with growth in at least one culture was 129 (51.4%). There was growth in a total of 227 cultures. The highest culture positivity rate was observed in respiratory tract samples (n = 94, 41.4%). Gram-negative bacterial pathogens (n = 130, 58.4%) predominated. Candida spp. was more frequent in urine cultures. The median day of the occurrence of secondary infection was 10 (range: 6-15). Patients who developed secondary infection had a longer LOS and higher mortality rate than patients who did not (p < 0.001).
Conclusions: Gram-negative secondary infections, predominantly in respiratory tract cultures, occurred in COVID-19 patients followed in the ICU. As a result, the LOS was prolonged and mortality rates increased.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2024 Erhan Ozyurt, Aylin Erman Daloglu, Kerem Inanoglu, Nilgun Kavrut Ozturk, Sadik Ozmen.)
Databáze: MEDLINE
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