Synthetic soldiers: Turning T cells into immortal warriors.
| Autor: | Restifo NP; Marble Therapeutics , Boston, MA, USA.; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA., Gattinoni L; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.; University of Regensburg , Regensburg, Germany.; Center for Immunomedicine in Transplantation and Oncology, University Hospital Regensburg , Regensburg, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of experimental medicine [J Exp Med] 2024 May 06; Vol. 221 (5). Date of Electronic Publication: 2024 Apr 18. |
| DOI: | 10.1084/jem.20240258 |
| Abstrakt: | The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine? (© 2024 Restifo and Gattinoni.) |
| Databáze: | MEDLINE |
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