Climate-related naturally occurring epimutation and their roles in plant adaptation in A. thaliana.

Autor: Chen B; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China.; College of Biology Resources and Environmental Sciences, Jishou University, Jishou, China., Wang M; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Guo Y; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Zhang Z; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Zhou W; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Cao L; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Zhang T; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Ali S; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Xie L; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China.; Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Science, Northeast Forestry University, Harbin, China., Li Y; College of Life Science, Northeast Forestry University, Harbin, China.; Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Science, Northeast Forestry University, Harbin, China., Zinta G; Integrative Plant AdaptOmics Lab (iPAL), Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur (CSIR-IHBT), Palampur, Himachal Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Sun S; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China., Zhang Q; State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.; The Center for Basic Forestry Research, College of Forestry, Northeast Forestry University, Harbin, China.; College of Life Science, Northeast Forestry University, Harbin, China.
Jazyk: angličtina
Zdroj: Molecular ecology [Mol Ecol] 2024 Nov; Vol. 33 (21), pp. e17356. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1111/mec.17356
Abstrakt: DNA methylation has been proposed to be an important mechanism that allows plants to respond to their environments sometimes entirely uncoupled from genetic variation. To understand the genetic basis, biological functions and climatic relationships of DNA methylation at a population scale in Arabidopsis thaliana, we performed a genome-wide association analysis with high-quality single nucleotide polymorphisms (SNPs), and found that ~56% on average, especially in the CHH sequence context (71%), of the differentially methylated regions (DMRs) are not tagged by SNPs. Among them, a total of 3235 DMRs are significantly associated with gene expressions and potentially heritable. 655 of the 3235 DMRs are associated with climatic variables, and we experimentally verified one of them, HEI10 (HUMAN ENHANCER OF CELL INVASION NO.10). Such epigenetic loci could be subjected to natural selection thereby affecting plant adaptation, and would be expected to be an indicator of accessions at risk. We therefore incorporated these climate-related DMRs into a gradient forest model, and found that the natural A. thaliana accessions in Southern Europe that may be most at risk under future climate change. Our findings highlight the importance of integrating DNA methylation that is independent of genetic variations, and climatic data to predict plants' vulnerability to future climate change.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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