Photoinduced Decarboxylative Difluoroalkylation and Perfluoroalkylation of α-Fluoroacrylic Acids.

Autor: Lu XY; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Huang R; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Wang ZZ; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Zhang X; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Jiang F; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Yang GX; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Shui FY; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Su MX; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Sun YX; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China., Sun HL; School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou 239000, China.
Jazyk: angličtina
Zdroj: The Journal of organic chemistry [J Org Chem] 2024 May 03; Vol. 89 (9), pp. 6494-6505. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1021/acs.joc.4c00684
Abstrakt: Herein, a novel and practical methodology for the photoinduced decarboxylative difluoroalkylation and perfluoroalkylation of α-fluoroacrylic acids is reported. A wide range of α-fluoroacrylic acids can be used as applicable feedstocks, allowing for rapid access to structurally important difluoroalkylated and polyfluoroalkylated monofluoroalkenes with high Z-stereoselectivity under mild conditions. The protocol demonstrates excellent functional group compatibility and provides a platform for modifying complex biologically active molecules.
Databáze: MEDLINE
Externí odkaz: