Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.

Autor:	André C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada., Martineau-Dussault MÈ; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada., Baril AA; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Marchi NA; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada.; Center for Investigation and Research in Sleep, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Laboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Daneault V; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada., Lorrain D; Research Centre on Aging, University Institute of Geriatrics of Sherbrooke, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada.; Department of Psychology, Université de Sherbrooke, Sherbrooke, QC, Canada., Hudon C; CERVO Brain Research Centre, Institut Universitaire en Santé Mentale de Québec, Québec City, QC, Canada.; School of Psychology, Université Laval, Québec City, QC, Canada., Bastien CH; CERVO Brain Research Centre, Institut Universitaire en Santé Mentale de Québec, Québec City, QC, Canada.; School of Psychology, Université Laval, Québec City, QC, Canada., Petit D; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychiatry, Université de Montréal, Montréal, QC, Canada., Thompson C; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada., Poirier J; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Douglas Mental Health University Institute, CIUSSS de l'Ouest-de-l'Ile-de-Montréal, Verdun, QC, Canada., Montplaisir J; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychiatry, Université de Montréal, Montréal, QC, Canada., Gosselin N; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada., Carrier J; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Recherche CIUSSS NIM, Montreal, QC, Canada.; Department of Psychology, Université de Montréal, Montreal, QC, Canada.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2024 Jul 11; Vol. 47 (7).
DOI:	10.1093/sleep/zsae094
Abstrakt:	Study Objectives: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status, and obstructive sleep apnea (OSA). Methods: A total of 198 dementia-free participants aged >55 years old (mean age: 68.7 ± 8.08 years old, 40.91% women, 41 APOE4 carriers) were recruited in this cross-sectional study. They underwent polysomnography, APOE4 genotyping, and a neuropsychological evaluation. ANCOVAs assessed the effect of APOE4 status on sleep architecture, controlling for age, sex, cognitive status, and the apnea-hypopnea index. Interaction terms were added between APOE4 status and covariates. Results: Rapid eye movement (REM) sleep percentage (F = 9.95, p = .002, ηp2 = 0.049) and duration (F = 9.23, p = .003, ηp2 = 0.047) were lower in APOE4 carriers. The results were replicated in a subsample of 112 participants without moderate-to-severe OSA. There were no significant interactions between APOE4 status and age, sex, cognitive status, and OSA in the whole sample. Conclusions: Our results show that APOE4 carriers exhibit lower REM sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance. (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.)
Databáze:	MEDLINE
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